2021 Fiscal Year Final Research Report
Does oral disease contribute to cardiac and skeletal muscle frailty?
Project/Area Number |
19K24109
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0907:Oral science and related fields
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Research Institution | Tsurumi University |
Principal Investigator |
ITO AIKO 鶴見大学, 歯学部, 助教 (70846401)
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Project Period (FY) |
2019-08-30 – 2022-03-31
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Keywords | 筋 / フレイル / 疾患モデル |
Outline of Final Research Achievements |
Occlusal disharmony has been suggested to increase sympathetic nerve activity and increase the onset of cardiac dysfunction. On the other hand, renin-angiotensin system (RAS) inhibitor captopril (Cpt) is most effective for preventing cardiac remodeling in patients with heart failure. This research thus hypothesized that Cpt might prevent cardiac dysfunction induced by occlusal disharmony using a bite-opening (BO) mouse model which was developed by cementing a suitable appliance onto the mandibular incisor. In Masson trichrome staining, the rate of fibrosis was significantly increased in the BO group, and its effect was suppressed in the BO + Cpt group. The rate of apoptosis in TUNEL staining was also significantly increased in the BO group, and its effect was suppressed in the BO + Cpt group. These results suggest that BO-mediated stress might induce cardiac apoptosis through the activation of RAS.
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Free Research Field |
生理学
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Academic Significance and Societal Importance of the Research Achievements |
咬合不調和は交感神経活動を増加させ、心機能の恒常性を阻害することが報告されている。また、レニンアンジオテンシン系(RAS)阻害剤であるカプトプリル(Cpt)は、心臓リモデリングに対する抑制効果をもつ有用な心不全治療薬である。本研究では、咬合異常が全身に与える影響を調べた。咬合異常による心筋の細胞死はRASの活性化を介して誘発される可能性が示唆された。
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