2020 Fiscal Year Final Research Report
The in vitro/in vivo study of CCN2 on dentin regeneration
| Project/Area Number |
19K24127
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
0907:Oral science and related fields
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
|---|
Principal Investigator |
QIU YOUJING 北海道医療大学, 歯学部, 研究員 (90845421)
|
|---|
| Project Period (FY) |
2019-08-30 – 2021-03-31
|
| Keywords | dental materials / dentin regeneration / odontoblasts / direct pulp capping / adhesives |
|---|
| Outline of Final Research Achievements |
I investigated the in vitro/in vivo effect of novel bioactive materials on MDPC-23 cells, human dental pulp stem cells (hDPSCs), and wistar rats as planned. The investigation of a novel adhesive monomer CMET on MDPC-23 cells has revealed that CMET stimulated MDPC-23 cells proliferation, differentiation and mineralization. The results have been published on on International Endodontic Journal (Int Endod J. 2020 Oct; 53(10):1413-1429). The investigation on hDPSCs has showed that CMET has low cytotoxicity and exhibits high activity on stimulation of odontogenic differentiation and matrix mineralization. The in vivo study on wistar rats showed that direct capping with CMET can effectively promote dentin bridge
formation.The results of the effect of CMET on dentin regeneration is under submission to SCI journal and patent application.
|
| Free Research Field |
口腔科学およびその関連分野
|
| Academic Significance and Societal Importance of the Research Achievements |
The successful completion of these studies will provide valuable results for the investigation of the development of novel dental materials. Besides, the result of these studies may change the current situation of direct pulp capping, and also provide new ideas for clinical treatments.
|
