GDF11 and myosatin expression in the oral and maxillofacial region

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24141
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Hayashi Yutaro 浜松医科大学, 医学部, 助教 (50845055)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: TGF-β superfamily. / GDF11 / myostatin / follistatin / BMP9 / adult neurogenesis

Outline of Final Research Achievements

GDF11 and myostatin are members of the transforming growth factor β (TGF-β) superfamily. Although they play pivotal roles during development, little information is available for the expression in the adult central nervous system. This research revealed follistatin and BMP9 expression in the adult rat central nervous system and suggested the idea that they play important roles in the adult neurogenesis.

Free Research Field

脳神経解剖学

Academic Significance and Societal Importance of the Research Achievements

本研究ではTGF-βスーパーファミリーに属するfollistatinとBMP9の成体ラット中枢神経系での発現分布を明らかにし、成体神経新生への可能性が示唆された。これまでこれらの因子は発生期における重要な機能のみが明らかになっていたが、成体における分子生物学的な機能が明らかになることで認知機能の低下を代表とする加齢変化に対する創薬につながると考えられる。