2020 Fiscal Year Final Research Report
Elucidation of extraction tooth socket healing mechanism and MRONJ pathological condition from the perspective of stem cell niche
| Project/Area Number |
19K24146
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2021-03-31
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| Keywords | MRONJ |
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| Outline of Final Research Achievements |
For the purpose of clarifying the onset mechanism of MRONJ, we have carried out the construction and evaluation of MRONJ like model mice, and the analysis using genetically modified mice. It was confirmed that the extraction socket of the MRONJ like model mouse did not heal even 4 weeks after the operation, and the bone around the extraction socket was necrotic. Furthermore, while a large number of mesenchymal stem cells were observed during the healing process of femoral fractures in genetically modified mice, most of the mesenchymal stem cells were not observed during the healing process of the extraction socket.
In this study, stem cells play an important role in bone marrow formation, suggesting that differences in the amount of mesenchymal stem cells during the wound healing process between the femur and the extraction socket may be involved in MRONJ development.
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| Free Research Field |
バイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化が進行する日本では骨粗鬆症患者も増加し続けている．骨粗鬆症の第１選択薬であるビスフォスフォネート (BP) 製剤だが強力な骨吸収抑制作用を持つ一方で，投与されている患者において侵襲的歯科治療などを引き金に顎骨壊死が発生するMRONJが社会的問題となっている．MRONJはその発症原因及び治療法も未だ解明されていない．本研究により抜歯を引き金に発生したMRONJの発生メカニズムには何らかの形で間葉系幹細胞が関わっていることが明らかとなった．今後はさらに詳細に検討していく予定である。これらの研究はこれまで解明されていない，MRONJのメカニズムおよび治療法の開発において大きな一歩である．
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