Incontinence-associated dermatitis by infected urine: biological mechanisms and prevention strategies

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K24194
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Koudounas Sofoklis 東京大学, 大学院医学系研究科(医学部), 特任助教 (70849968)
• Project Period (FY): 2019-08-30 – 2022-03-31
• Keywords: IAD / skin barrier / incontinence / older patients

Outline of Final Research Achievements

Therefore, in the next step I wanted to develop a novel animal model for IAD by combing urine and bacteria. My studies showed that bacteria on damaged skin, have the ability to invade the epidermis and this induces IAD which is characterized by skin barrier disruption, inflammation and persistent redness. I have presented my research findings at national and international conferences and received the Young Investigator award by the Japanese Society for Wound Healing.

Free Research Field

Nursing Science

Academic Significance and Societal Importance of the Research Achievements

My research findings are important for the development of new innovative prevention/treatment strategies for IAD. The animal model I have established can serve as the basis for future studies to test the effectiveness of novel strategies to prevent the development of IAD.