Sex-specific impacts of gene and environmental factors on diabetic complications

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24229
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Kyushu University
• Principal Investigator: Toshiaki Ohkuma 九州大学, 大学病院, 助教 (20709258)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 糖尿病 / コホート研究 / 性差

Outline of Final Research Achievements

Although sex differences in the incidence of diabetic complications have been observed mainly in Western countries, few studies have examined this issue in Japan. We therefore constructed genomic cohort study comprising 5131 Japanese patients with diabetes attending diabetes centers in Fukuoka Prefecture. In this study, we investigated sex differences in the incidence of diabetic complications, and sex-specific associations of environmental and genetic factors with diabetic complications and its risk factors.

Free Research Field

糖尿病学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、糖尿病患者の死亡率や糖尿病合併症の発症率に性差があることや、合併症の危険因子が合併症の発症に及ぼす影響にも性差があることが示された。このように、我が国の糖尿病患者の大規模コホートをもとにしたエビデンスにより、我が国における性差医学・医療の推進・発展に貢献することができると考える。