2022 Fiscal Year Final Research Report
Development of a new treatment strategy for patients with esophageal cancer using a combination of exercise and nutritional therapy
Project/Area Number |
19K24301
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Kansai Medical University (2022) National Cancer Center Japan (2019-2021) |
Principal Investigator |
FUKUSHIMA Takuya 関西医科大学, リハビリテーション学部, 助教 (50779535)
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Project Period (FY) |
2019-08-30 – 2023-03-31
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Keywords | 食道がん / サルコペニア / 身体活動量 / 栄養 / 運動療法 / 栄養療法 / がん |
Outline of Final Research Achievements |
In this study, we found that low physical activity and malnutrition are key factors that influence preoperative muscle dysfunction in patients with esophageal cancer. Exercise instruction during preoperative chemotherapy may be effective in improving muscle dysfunction. In addition, a certain number of patients had low physical activity despite exercise instruction, which might have impacted their prognosis. Although we repeatedly investigated the effect of intervention with nutritional therapy using HMB, we could not conduct intervention studies due to the influence of COVID-19, and this remains an issue for the future.
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Free Research Field |
リハビリテーション
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Academic Significance and Societal Importance of the Research Achievements |
これまでに食道がん患者が呈することの多い術前筋機能障害の要因を検索した報告はなく,介入の糸口を掴んだ本研究成果は新規性が高いと言える.現在の周術期リハビリテーションの中でもprehabilitationに代表される術前リハビリテーションの必要性が高まる一方で,マンパワーや体制の未確立が介入の大きな阻害因子となっている.本研究で示した運動指導による筋機能への効果は学術的側面のみならず実装可能性が高いという点において社会的意義は高く汎化性も兼ね備えていると考えられる.
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