2021 Fiscal Year Final Research Report
Early diagnosis of atherosclerosis by accurate ultrasonic measurement of surface roughness of internal elastic membrane
| Project/Area Number |
19KK0100
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 21:Electrical and electronic engineering and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
Kanai Hiroshi 東北大学, 工学研究科, 教授 (10185895)
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| Co-Investigator(Kenkyū-buntansha) |
荒川 元孝 東北大学, 医工学研究科, 准教授 (00333865)
森 翔平 東北大学, 工学研究科, 助教 (50815149)
高瀬 圭 東北大学, 医学系研究科, 教授 (60361094)
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| Project Period (FY) |
2019-10-07 – 2022-03-31
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| Keywords | 動脈内膜弾性板 / 表面粗さ計測 / 超音波医学 / 粥状動脈硬化症 / 医用超音波計測 / 非侵襲的早期診断 / 超音波工学 / 位相差トラッキング法 |
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| Outline of Final Research Achievements |
We have developed a method to exclude unnatural shapes at both ends of the surface shape measured for each beam by limiting the analysis range to the monotonically increasing part of the lateral displacement when measuring the surface shape for each beam. Furthermore, by interpolating the surface shape measured for each beam for each 1-micron lateral position, the error power is calculated with equal weight at all lateral positions of the surface shape measured for each beam, and the height is adjusted appropriately. We also developed a method. As a result, it became possible to obtain carotid artery surface roughness in vivo by reducing the beam-to-beam variation after adjusting the height of the surface shape measured for every single beam. These results were obtained by referring to Professor Wilhjelm's many years of research.
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| Free Research Field |
医用超音波工学
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| Academic Significance and Societal Importance of the Research Achievements |
高血圧にさらされることで家兎の頸動脈内腔表面が十数μmの粗さを持つことが報告されており，超音波を用いて非侵襲的に頸動脈後壁の内腔表面の形状の変化を計測することで，動脈硬化症の極早期診断へ貢献できる可能性がある。しかし，超音波ビームを走査して得られるBモード断層像では，プローブと血管前壁間の音速不均一領域の影響により，μm オーダの精度で表面形状を計測することが困難である。本研究では，この数マイクロメータの表面形状を非侵襲的に計測することを世界で初めて可能としたもので，学術的意義や社会的意義は大きい。
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