Development of novel method to protect lung function using an extracorporeal lung perfusion device targeting lungs from donetion after circulatory death donors.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19KK0223
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Tohoku University
• Principal Investigator: Niikawa Hiromichi 東北大学, 大学病院, 講師 (80636027)
• Co-Investigator(Kenkyū-buntansha): 迫田 大輔 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (40588670) ; 岡田 克典 東北大学, 加齢医学研究所, 教授 (90323104) ; 渡辺 有為 東北大学, 大学病院, 助教 (20724199) ; 田中 遼太 東北大学, 大学病院, 特任助手 (40647450)
• Project Period (FY): 2019-10-07 – 2023-03-31
• Keywords: 心臓死ドナー / 体外肺灌流 / 温虚血時間

Outline of Final Research Achievements

The aim of this study was to establish a protocol for rapid cooling of donor lungs from donation after circulatory death donors without surgical interventions. We hypothesized that it would be possible to cool the lungs by immersing the entire donor body in a refrigerant using a cold basin. By combining a cold basin using a special cryogenic refrigerant and a refrigerant circulation system, we were able to reduce the tracheal temperature from 37°C to 28°C within 90 minutes after cardiac arrest. Therefore, we evaluated lung function by 2 hours of ex vivo lung perfusion (EVLP) using uncooled donor lungs as controls (n = 5) and lungs from the cooled group (n = 5). All lungs in the cooled group were deemed suitable for transplantation.

Free Research Field

呼吸器外科

Academic Significance and Societal Importance of the Research Achievements

心停止ドナー肺の機能を維持する有効な方法として、外科処置を必要としない冷温槽を用いた新規冷却方法を提案し、動物実験を通してその有効性を確認することができた。今後、積極的な心停止ドナー肺を用いた肺移植の増加に貢献するものと考えられる。