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2019 Fiscal Year Research-status Report

Reduction of death from colorectal cancer with help of artificial intelligence

Research Project

Project/Area Number 19KK0421
Research InstitutionShowa University

Principal Investigator

森 悠一  昭和大学, 医学部, 講師 (20459209)

Project Period (FY) 2019 – 2021
Keywords人工知能 / 内視鏡 / 大腸癌 / 大腸ポリープ
Outline of Annual Research Achievements

本国際研究では、人工知能(AI)を利用した大腸内視鏡検査により、「命を救える」ことを証明する。共同研究者である三澤将史らが中心となって開発した内視鏡用AIは内視鏡検査中に大腸ポリープ等を自動で検出し、医師の見落としを予防することが期待されている(Misawa M, Kudo S, Mori Y, et al. Gastroenterology 2018)。このAIによって、将来の癌死が実際に抑制できるかどうかを検証することが、本研究の目的である。
具体的には、内視鏡疫学研究の先駆者であるオスロ大学の協力のもと、ノルウェー独自の「死亡データが自動リンクする公的検診レジストリー」を研究利用することで、超低コストで大規模前向き試験(N=10,000)を実施する。介入後の10年間の予後追跡ができる研究基盤を作ることが本研究の要旨である。
日本で開発した内視鏡AIをあえてノルウェーに持ち込むことで、立証困難であったエビデンスを構築し、世界の大腸癌死亡者数減少にいち早く貢献することが、本研究の目的である。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

2019年度は、オスロ大学との緊密な連携を確認するとともに研究プロトコルの基軸部分を作成し、2020年度からの本格的な展開の準備作業を行った。これは当初の想定内の研究内容である。

Strategy for Future Research Activity

2020年度中にプロトコルを作成し、研究開始ができるようノルウェーでの体制(データセンター・IRB・加入病院との連携・AI機器の搬入)を整備する。

  • Research Products

    (16 results)

All 2020 2019

All Journal Article (16 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 16 results)

  • [Journal Article] Can artificial intelligence standardise colonoscopy quality?2020

    • Author(s)
      Mori Yuichi、Kudo Shin-ei、Misawa Masashi
    • Journal Title

      The Lancet Gastroenterology & Hepatology

      Volume: 5 Pages: 331~332

    • DOI

      10.1016/S2468-1253(19)30407-8

    • Peer Reviewed
  • [Journal Article] How Far Will Clinical Application of AI Applications Advance for Colorectal Cancer Diagnosis?2020

    • Author(s)
      Mori Y, Kudo SE, Misawa M, Takeda K, Kudo T, Itoh H, Oda M, Mori K.
    • Journal Title

      J Anus Rectum Colon

      Volume: 2 Pages: 47-50

    • DOI

      10.23922/jarc.2019-045.

    • Peer Reviewed
  • [Journal Article] Proceedings from the First Global Artificial Intelligence in Gastroenterology and Endoscopy Summit.2020

    • Author(s)
      Parasa S, Wallace M, Bagci U, Antonino M, Berzin T, Byrne M, Celik H, Farahani K, Golding M, Gross S, Jamali V, Mendonca P, Mori Y, Ninh A, Repici A, Rex D, Skrinak K, Thakkar SJ, van Hooft JE, Vargo J, Yu H, Xu Z, Sharma P.
    • Journal Title

      Gastrointest Endosc.

      Volume: in press Pages: in press

    • DOI

      10.1016/j.gie.2020.04.044.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment policy for colonic laterally spreading tumors based on each clinicopathological feature of 4 subtypes: actual status of pseudo-depressed type.2020

    • Author(s)
      Ishigaki T, Kudo SE, Miyachi H, Hayashi T, Minegishi Y, Toyoshima N, Misawa M, Mori Y, Kudo T, Wakamura K, Baba T, Sawada N, Ishida F, Hamatani S.
    • Journal Title

      Gastrointest Endosc

      Volume: in press Pages: in press

    • DOI

      10.1016/j.gie.2020.04.033.

    • Peer Reviewed
  • [Journal Article] Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video).2020

    • Author(s)
      Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K.
    • Journal Title

      Gastrointest Endosc.

      Volume: in press Pages: in press

    • DOI

      10.1016/j.gie.2020.03.3759.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI.2020

    • Author(s)
      Kataoka S, Kudo SE, Misawa M, Nakamura H, Takeda K, Toyoshima N, Mori Y, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Baba T, Ishida F.
    • Journal Title

      Endosc Int Open

      Volume: 3 Pages: E360-E367

    • DOI

      10.1055/a-1068-9228.

    • Peer Reviewed
  • [Journal Article] Endocytoscopic intramucosal capillary network changes and crypt architecture abnormalities can predict relapse in patients with an ulcerative colitis Mayo endoscopic score of 1.2020

    • Author(s)
      Maeda Y, Kudo SE, Ogata N, Mori Y, Misawa M, Homma M, Nemoto T, Ogawa M, Sasanuma S, Sato Y, Kataoka S, Kouyama Y, Sakurai T, Igarashi K, Ogawa Y, Kato K, Ichimasa K, Nakamura H, Kudo T, Hayashi T, Wakamura K, Baba T, Inoue H, Ohtsuka K.
    • Journal Title

      Dig Endosc

      Volume: in press Pages: in press

    • DOI

      10.1111/den.13655.

    • Peer Reviewed
  • [Journal Article] Endocytoscopy for the differential diagnosis of colorectal low-grade adenoma: a novel possibility for the "resect and discard" strategy.2020

    • Author(s)
      Kudo T, Suzuki K, Mori Y, Misawa M, Ichimasa K, Takeda K, Nakamura H, Maeda Y, Ogawa Y, Hayashi T, Wakamura K, Ishida F, Inoue H, Kudo SE.
    • Journal Title

      Gastrointest Endosc

      Volume: 3 Pages: 676-683

    • DOI

      10.1016/j.gie.2019.11.029.

    • Peer Reviewed
  • [Journal Article] Simultaneous detection and characterization of diminutive polyps?with?the use of artificial intelligence during colonoscopy2019

    • Author(s)
      Mori Yuichi、Kudo Shin-ei、Misawa Masashi、Mori Kensaku
    • Journal Title

      VideoGIE

      Volume: 4 Pages: 7~10

    • DOI

      10.1016/j.vgie.2018.10.006

    • Peer Reviewed
  • [Journal Article] Stable polyp-scene classification via subsampling and residual learning from an imbalanced large dataset2019

    • Author(s)
      Itoh Hayato、Roth Holger、Oda Masahiro、Misawa Masashi、Mori Yuichi、Kudo Shin-Ei、Mori Kensaku
    • Journal Title

      Healthcare Technology Letters

      Volume: 6 Pages: 237~242

    • DOI

      10.1049/htl.2019.0079

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Correction: Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2019.2019

    • Author(s)
      Bisschops R, East JE, Hassan C, Hazewinkel Y, Kaminski MF, Neumann H, Pellis M, Antonelli G, Bustamante Balen M, Coron E, Cortas G, Iacucci M, Yuichi M, Longcroft-Wheaton G, Mouzyka S, Pilonis N, Puig I, van Hooft JE, Dekker E.
    • Journal Title

      Endoscopy

      Volume: in press Pages: in press

    • DOI

      10.1055/a-1074-5788.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms.2019

    • Author(s)
      Kudo SE, Misawa M, Mori Y, Hotta K, Ohtsuka K, Ikematsu H, Saito Y, Takeda K, Nakamura H, Ichimasa K, Ishigaki T, Toyoshima N, Kudo T, Hayashi T, Wakamura K, Baba T, Fumio I, Inoue H, Itoh H, Oda M, Mori K.
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: in press Pages: in press

    • DOI

      10.1016/j.cgh.2019.09.009.

    • Peer Reviewed
  • [Journal Article] The ability of positron emission tomography/computed tomography to detect synchronous colonic cancers in patients with obstructive colorectal cancer2019

    • Author(s)
      Maeda Chiyo、Endo Shungo、Mori Yuichi、Mukai Shumpei、Hidaka Eiji、Ishida Fumio、Kudo Shin-Ei
    • Journal Title

      Molecular and Clinical Oncology

      Volume: NA Pages: NA

    • DOI

      10.3892/mco.2019.1815

    • Peer Reviewed
  • [Journal Article] Artificial intelligence for early gastric cancer: early promise and the path ahead.2019

    • Author(s)
      Mori Y, Berzin TM, Kudo SE.
    • Journal Title

      Gastrointest Endosc

      Volume: 4 Pages: 816-817

    • DOI

      10.1016/j.gie.2018.12.019.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Artificial intelligence and colonoscopy: Current status and future perspectives2019

    • Author(s)
      Kudo Shin‐ei、Mori Yuichi、Misawa Masashi、Takeda Kenichi、Kudo Toyoki、Itoh Hayato、Oda Masahiro、Mori Kensaku
    • Journal Title

      Digestive Endoscopy

      Volume: 31 Pages: 363-371

    • DOI

      10.1111/den.13340

    • Peer Reviewed
  • [Journal Article] Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective.2019

    • Author(s)
      Mori Y, Kudo SE, Mohmed HEN, Misawa M, Ogata N, Itoh H, Oda M, Mori K.
    • Journal Title

      Dig Endosc

      Volume: 4 Pages: 378-388

    • DOI

      10.1111/den.13317.

    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2021-01-27  

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