Comprehensive study of innate immunity

2012 Fiscal Year Final Research Report

• Project/Area Number: 20002008
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: AKIRA Shizuo 大阪大学, 免疫学フロンティア研究センター, 教授 (50192919)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Osamu 大阪大学, 微生物病研究所, 准教授 (10379092) ; KAWAI Taro 大阪大学, 微生物病研究所, 准教授 (50456935) ; SAITOH Tatsuya 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (60456936) ; SATOH Takashi 大阪大学, 免疫学フロンティア研究センター, 特任助教 (60619716)
• Project Period (FY): 2008 – 2012
• Keywords: 自然免疫 / 炎症性疾患 / 感染症 / サイトカイン / インターフェロン

Research Abstract

Innate immune system is critically involved in host defense and inflammation. Innate immune system senses microbial components by pattern-recognition receptors and induces host defense response. However, innate immune system also senseshost-derived stimulatory factors and often causes development of inflammatory diseases. We have conducted a comprehensive study of innate immunity, and have revealed mechanisms underlying development of infectious and inflammatory diseases

Research Products

• [Journal Article] Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroprosis. (2013)
  • Author(s): Zou J, Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, Akira S.
  • Journal Title: Immunity. Volume: 38(49) Pages: 717-728
  • DOI: doi:10.1016/j.immuni.2012.12.007
  • Peer Reviewed
• [Journal Article] Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis. (2013)
  • Author(s): Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
  • Journal Title: Nature Volume: 495(7442) Pages: 524-528
  • DOI: doi: 10.1038/nature11930
  • Peer Reviewed
• [Journal Article] Microtubue-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. (2013)
  • Author(s): Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S.
  • Journal Title: Nat Immunol. Volume: 14(5) Pages: 454-460
  • DOI: doi: 10.1038/ni.2550
  • Peer Reviewed
• [Journal Article] The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation. (2012)
  • Author(s): Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira, S.
  • Journal Title: Immunity. Volume: 37(6) Pages: 1024-1036
  • DOI: doi: 10.1016/j.immuni.2012.08.022
  • Peer Reviewed
• [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. (2012)
  • Author(s): Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S.
  • Journal Title: Cell Host Microbe. Volume: 12(1) Pages: 109-116
  • DOI: doi: 10.1016/j.chom. 2012.05.015.
  • Peer Reviewed
• [Journal Article] Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. (2011)
  • Author(s): Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
  • Journal Title: Immunity. Volume: 34 Pages: 352-363
  • DOI: doi: 10.1016/j.immuni.2011.03.010
  • Peer Reviewed
• [Journal Article] The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. (2011)
  • Author(s): Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
  • Journal Title: Nat Immunol. Volume: 12 Pages: 1167-1175
  • DOI: doi:10.1038/ni.2137
  • Peer Reviewed
• [Journal Article] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. (2010)
  • Author(s): Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.
  • Journal Title: Immunity. Volume: 35(59) Pages: 765-776
  • DOI: doi:10.1016/j.immuni.2010.010.013.
  • Peer Reviewed
• [Journal Article] The Jmjd3-Irf4 axis regulates M2 macropharge polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Kumagai Y, Miyake T, Matsuyama T, Yui K, Okazaki T, Saitoh T, Honma K, Nakai,K Akira S.
  • Journal Title: Nat Immunol. Volume: 11(10) Pages: 936-944
  • DOI: doi: 10.1038/ni.1920.
  • Peer Reviewed
• [Journal Article] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. (2009)
  • Author(s): Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S.
  • Journal Title: Nat Immunol. Volume: 10(9) Pages: 965-972
  • DOI: doi:10.1038/ni.1771
  • Peer Reviewed
• [Journal Article] Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. (2009)
  • Author(s): Matsushita K, Takeuchi O, Standley D, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S.
  • Journal Title: Nature. Volume: 458(7242) Pages: 1185-1190
  • DOI: doi:10.1038/nature07924
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. (2008)
  • Author(s): Saitoh T, Fujita N, Jang M.H, Uematsu S, Yang B.G, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
  • Journal Title: Nature. Volume: 456(7219) Pages: 264-268
  • DOI: doi:10.1038/nature07383
  • Peer Reviewed
• [Journal Article] Regulation of humoral and cellular gut immunityby lamina propria dendritic cells expressing Toll-like receptor 5. (2008)
  • Author(s): Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T,Yamamoto M, Yokoda Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
  • Journal Title: Nat Immunol. Volume: 9(7) Pages: 769-776
  • DOI: doi:10.1038/ni.1622.
  • Peer Reviewed
• [Presentation] (2012)
  • Author(s): 審良静男、自然免疫
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-05
• [Presentation] Innate Immune Responses (2012)
  • Author(s): Akira S
  • Organizer: EUROPEAN CONGRESS OF IMMUNOLOGY
  • Place of Presentation: Scottish Exhibition & Conference Centre (Scotland)
  • Year and Date: 2012-09-06
• [Presentation] Nucleic Acids Sensing by innate immunity. (2011)
  • Author(s): Akira S
  • Organizer: International Union of Microbiological Societies 2011 Congress(IUMS2011).
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-09-16
• [Presentation] Innate Immune Regulation revealed by gene targeting (2011)
  • Author(s): Akira S
  • Organizer: Toll2011
  • Place of Presentation: Riva del Garda Congress Center(Italy)
  • Year and Date: 2011-05-04
• [Presentation] Roles of TLR inducible genes revealed by gene targeting (2010)
  • Author(s): Akira S.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-23
• [Presentation] Functional Analysis of TLR Inducible Genes by Gene Targeting (2010)
  • Author(s): Akira S
  • Organizer: Keystone Symposia.
  • Place of Presentation: Trinity College Dublin (Ireland)
  • Year and Date: 2010-06-08
• [Presentation] Zc3h12a, a negative regulator in the TLR response (2009)
  • Author(s): Akira S
  • Organizer: Cellular and Cytokine Interactions in Health and Disease 2009
  • Place of Presentation: The Lisbon Congress Center(Portugal)
  • Year and Date: 2009-10-19
• [Presentation] Zc3h12, a TLR inducibleribonuclease involved in IL-6mRNA dearadation. (2009)
  • Author(s): Akira S.
  • Organizer: The First International Kishimoto Foundation Symposium.
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-25
• [Presentation] 自然免疫の最近の進歩 (2008)
  • Author(s): 審良静男
  • Organizer: 第38回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-01
• [Presentation] Atg16L1, an autophagy protein (2008)
  • Author(s): Akira S
  • Organizer: controls endotoxin-induced inflammasome activation. Toll2008
  • Place of Presentation: Hotel Cascais Miragem (Portgual)
  • Year and Date: 2008-09-25
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html