2012 Fiscal Year Final Research Report
Regulation of cell behavior through the interplays of cadherin cell adhesion molecules and cytoskeleton
| Project/Area Number |
20002009
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKEICHI Masatoshi 独立行政法人理化学研究所, 高次構造形成研究グループ, グループディレクター (00025454)
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| Project Period (FY) |
2008 – 2012
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| Keywords | カドヘリン / カテニン / アクチン / 微小管 / 細胞接着 |
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| Research Abstract |
We investigated the mechanisms of the cooperation between cadherin superfamily members and cytoskeletal proteins. The findings include 1) EPLIN is involved in the epithelial to mesenchymal transition of junctional architecture, 2) Fat4 and Dachsous1 are required for apical domain formation in neuroepithelial cells, 3) Willin regulates junctional constriction, 4) Celr1 is required for PCP formation of the neural plate, 5) protocadherin17 regulates collective axon extension. Furthermore, we identified Nezha/CAMSAP3 as a microtubule minus-end anchoring protein, and thereby advanced the research fields of non-centrosomal microtubules.
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[Journal Article] Nectins establish a checkerboard-like cellular pattern in the auditory epithelium2011
Author(s)
Togashi, H., Kominami, K., Waseda, M., Komura, H., Miyoshi, J., Takeichi, M., and Takai, Y
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Journal Title
Science
Volume: 333
Pages: 1144-1147
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