2012 Fiscal Year Final Research Report
Molecular mechanisms of chromosome assembly mediated by condensins
| Project/Area Number |
20002010
|
|---|
| Research Category |
Grant-in-Aid for Specially Promoted Research
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
HIRANO Tatsuya 独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 主任研究員 (50212171)
|
|---|
| Project Period (FY) |
2008 – 2012
|
| Keywords | 染色体 / コンデンシン・細胞周期 / 有糸分裂 / 減数分裂 |
|---|
| Research Abstract |
The assembly and segregation of chromosomes represent two of the fundamental processes that ensure faithful inheritance and expression of the genetic information. In the current study, we have investigated the structure, function and regulation of condensins (and cohesins) that play central roles in these processes. A wide variety of experimental systems (frog egg extracts, tissue culture cells, mouse oocytes, and red-algal and bacterial cells) and interdisciplinary approaches (cell biology, molecular genetics, biochemistry, and structural biology) were effectively combined, leading to an integrated picture of how this highly sophisticated class of molecular machines might work in vivo and in vitro. The outcome of the current study also expanded and deepened our evolutionary insights into chromosome architecture and the etiology of a human disease accompanying condensin’s misregulation.
|
-
-
-
-
-
-
[Journal Article] An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin2012
Author(s)
Shiheido, H., Y. Naito, H. Kimura, H. Genma, H. Takashima, T. Ono, T. Hirano, W. Du, T. Yamada, N. Doi, S. Iijima, Y. Hattori and H. Yanagawa
-
Journal Title
II. PLOS ONE
Volume: 7(9)
Pages: e44889
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] The chromosomal association of condensin II is regulated by a non-catalytic action of PP2A2009
Author(s)
Takemoto, A., K. Maeshima, T. Ikehara, K. Yamaguchi, A. Murayama, S. Imamura, N. Imamoto, S. Yokoyama, T. Hirano, Y. Watanabe, F. Hanaoka, J. Yanagisawa, and K. Kimura
-
Journal Title
Nat. Struct Mol. Biol.
Volume: 16
Pages: 1302-1308
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
