2009 Fiscal Year Final Research Report
Development of nanocarrier for cancer immunotherapy
| Project/Area Number |
20011002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKIYOSHI Kazunari Tokyo Medical and Dental University, 生体材料工学研究所, 教授 (90201285)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌免疫 / サイトカイン / ナノゲル / 遺伝子デリバリー / 分子シャペロン / カチオン性多糖 |
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| Research Abstract |
Raspberry-like assembly of polysaccharide nanogels with a high potential as a carrier for protein delivery was prepared. The present study proposes a novel therapeutic intervention technology, taking advantage of slow and sustained release of bioactive cytokines such as IL12. New siRNA or CpG DNA delivery systems were also developed by functional cycloamylose nanogels.
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