2009 Fiscal Year Final Research Report
Role of activation-induced cytidine deaminase (AID) in the mutation induction during H.pylori-induced gastric carcinogenesis.
Project/Area Number |
20012029
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
CHIBA Tsutomu Kyoto University, 医学研究科, 教授 (30188487)
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Co-Investigator(Renkei-kenkyūsha) |
MARUSAWA Hiroyuki 京都大学, 医学研究科, 講師 (80324630)
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Project Period (FY) |
2008 – 2009
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Keywords | AID / H.pylori / 胃癌 / CagA / 4型分泌装置 / 遺伝子不安定性 |
Research Abstract |
H.pylori enhances gastric cancer development through gastritis. In this study, we found that H.pylori infection induces AID expression, a member of APOBEC family protein, in the gastric mucosal cells, resulting in accumulation of various gene mutations. In addition, AID expression by H.pylori infection also causes not only loss but also gain of various genes, thus contributing to genome instability.
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Research Products
(36 results)
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[Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009
Author(s)
Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki I, Honjo T, Chiba T, Kinoshita K
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Journal Title
Oncogene 28
Pages: 469-478
Peer Reviewed
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[Journal Article] Expression profile of REG family proteins, REG Iα and REGIV in advanced gastric cancer: Comparison with mucinous phenotype and prognostic markers.2009
Author(s)
Yamagishi H, Fukui H, Sekikawa A, Kono T, Fujii S, Ichikawa K, Tomita S, Imura J, Hiraishi H, Chiba T, Fujimori T
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Journal Title
Modern Pathol 22
Pages: 906-913
Peer Reviewed
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