2009 Fiscal Year Final Research Report
Regulation of transformation and cell growth by molecules controlling cell death
| Project/Area Number |
20013020
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
YONEHARA Shin Kyoto University, 大学院・生命科学研究科, 教授 (00124503)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞死 / 遺伝子 / 癌 / 細胞・組織 / シグナル伝達 |
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| Research Abstract |
We show that tetraploid cells induced by impaired mitotic chromosomal condensation are eliminated by a novel type of cell death different from caspase-dependent apoptosis. The cell death was executed by the downregulation of eukaryotic translation elongation factor 1 alpha 1 (eEF1A1), a typical housekeeping gene products. The downregulation of eEF1A1 expression was shown to be induced by both destabilization of its mRNA and its translational inhibition.
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