2009 Fiscal Year Final Research Report
Redox signaling and cancer formation
| Project/Area Number |
20013025
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
MIKI Hiroaki Osaka University, 蛋白質研究所, 教授 (80302602)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Wnt / Dishevelled (Dvl) / nucleoredoxin (NRX) / がん |
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| Research Abstract |
I investigated the function of NRX that binds to Dvl, a Wnt signal transducer. Mice deficient for NRX gene were perinatally lethal and showed abnormal development of their bones and heart. Wnt signaling was hyperactivated in cells obtained form calvaria, but was downregulated in cells from the heart. This unexpected decrease in the activity of Wnt signaling was due to the reduction of Dvl proteins caused by augmented ubiquitination. Also, I discovered that Fli-I is a novel binding partner for NRX, and found that NRX inhibits the innate immune response by linking Fli-I to MyD88.
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Research Products
(13 results)
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[Journal Article] Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.2010
Author(s)
Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka S, Nishinakamura R
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Journal Title
Proc. Natl. Acad. Sci. USA (in press)
Peer Reviewed
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[Journal Article] Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing identifies a splice-site mutation in nucleoredoxin.2009
Author(s)
Boles MK, Wilkinson BM, Wilming L, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marcin-Garcia P, Mattews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ, Justice MJ.
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Journal Title
PLoS Genet. 5
Pages: e1000759
Peer Reviewed
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