2009 Fiscal Year Final Research Report
Identification of tyrosine phosphorylated proteins in scirrhous cancer
| Project/Area Number |
20013050
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Akita University |
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Principal Investigator |
TANAKA Masamitsu Akita University, 大学院・医学系研究科, 教授 (20291396)
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| Project Period (FY) |
2008 – 2009
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| Keywords | スキルス / 胃癌 / リン酸化 / Src / チロシンキナーゼ / ephrin / 酸化ストレス |
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| Research Abstract |
In an attempt to identify phosphotyrosine containing proteins binding to Src family kinases (SFKs) in gastric scirrhous carcinoma, we identified Ossa/C9orf10, CDCP1 and ARAP3. Among them, Ossa, designated as Oxidative stress-associated Src activator is a novel RNA-binding protein that guards cancer cells from oxidative stress-induced apoptosis by the activation of PI3-kinase/Akt signaling through SFKs. Dissemination of intraperitoneally transplanted scirrhous gastric cancer cells was suppressed by reduced expression of Ossa or CDCP1, or treatment with synthetic peptide derived from ephrin-B1 carboxyl-terminus.
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