2009 Fiscal Year Final Research Report
Risk assessment of cancer using telomere G-tail length measurement
| Project/Area Number |
20014015
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hiroshima University |
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Principal Investigator |
TAHARA Hidetoshi Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (00271065)
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| Co-Investigator(Renkei-kenkyūsha) |
ANNO Kumiko 広島大学, 大学院・医歯薬学総合研究科, 助教 (30452585)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Gテール / テロメア / がん / リスク診断 |
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| Research Abstract |
We have previously developed the assay to measure the G-tail length, so-called G-tail telomere hybridization protection assay (HPA). We also developed the kit and the high-throughput automated machine for G-tail measurement. We applied these technologies for not only basic research but also for the clinical research, and found that peripheral blood from gastrointestinal cancer patients exhibited significant shorter average G-tail lengths than non-cancerous control group. Whereas total telomere length also reduced in cancer patients, G-tail lengths are markedly reduced in gastrointestinal cancer patients. These findings suggest that G-tail length can be a useful marker for the cancer risk assessment.
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