2009 Fiscal Year Final Research Report
Development of tumor-specific immunotherapy based on the analysis of functions of dendritic cells
| Project/Area Number |
20015016
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAHARA Hideaki The University of Tokyo, 医科学研究所, 教授 (70322071)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 免疫学 / がん治療 / 樹状細胞 / サイトカイン / 遺伝子治療 |
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| Research Abstract |
Dendritic cells (DCs) are the immune cells which direct the immune responses of the host. It has been conceived that the examination on the DCs could lead to the development of effective immunological therapy against cancer. In this project, we have found using mouse tumor systems that systemic administration of IL-23, a cytokine secreted by DCs, and blocking antibody against Milk Fat Globule EGF-8(MFG-E8) could be effective cancer immunotherapy.
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Research Products
(10 results)
