Development of tumor-specific immunotherapy based on the analysis of functions of dendritic cells

2009 Fiscal Year Final Research Report

• Project/Area Number: 20015016
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TAHARA Hideaki The University of Tokyo, 医科学研究所, 教授 (70322071)
• Project Period (FY): 2008 – 2009
• Keywords: 免疫学 / がん治療 / 樹状細胞 / サイトカイン / 遺伝子治療

Research Abstract

Dendritic cells (DCs) are the immune cells which direct the immune responses of the host. It has been conceived that the examination on the DCs could lead to the development of effective immunological therapy against cancer. In this project, we have found using mouse tumor systems that systemic administration of IL-23, a cytokine secreted by DCs, and blocking antibody against Milk Fat Globule EGF-8(MFG-E8) could be effective cancer immunotherapy.

Research Products

• [Journal Article] Milk Fat Globule EGF-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. (2009)
  • Author(s): Jinushi M, Sato M, Kanamoto A, Itoh A, Nagai S, Koyasu S, Dranoff G, Tahara H.
  • Journal Title: J Exp. Med. 206 Pages: 1317-1326
• [Journal Article] Cytokine gene-mediated immunotherapy: Current status and future perspectives. (2009)
  • Author(s): Jinushi M, Tahara H
  • Journal Title: Cancer Science 100 Pages: 1389-1396
• [Journal Article] Emerging concepts in biomarker discovery (2009)
  • Author(s): Tahara H., et, al
  • Journal Title: J Translational Med 7 Pages: 45-69
• [Journal Article] Induction of anti-tumor immune response by homeostatic proliferation and CD28 signaling. (2008)
  • Author(s): Suzuki T, Ogawa S, Tanabe K, Tahara H, Abe R, Kishimoto H.
  • Journal Title: J Immunol 180 Pages: 4596-4605
• [Journal Article] Vaccination with Epitope Peptide Derived from Human VEGF Receptor 2 Prevent Choroidal Neovascularization in an Animal Model. (2008)
  • Author(s): Takahashi H, Ishizaki H, Tahara H, Tamaki Y, Yanagi Y.
  • Journal Title: Investigative Ophthalmology & Visual Science 49 Pages: 2143-2147
• [Journal Article] Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic anti-tumor immunity. (2008)
  • Author(s): Saito T, Takayama T, Osaki T, Nagai S, Suzuki T, Sato M, Kuwano H, Tahara H.
  • Journal Title: Cancer Sci. 99 Pages: 2028-36
• [Presentation] Antigen-specific antitumor effects of DNA vaccine are significantly enhanced with systemic administration of interleukin (IL)-23 (2009)
  • Author(s): 米山公康、田原秀晃, 他3名
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-04
• [Presentation] Cancer vaccination using tumor cells in situ as the source of tumor antigens (2009)
  • Author(s): 田原秀晃
  • Organizer: (シンポジウム)日本癌学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-03
• [Presentation] Cancer vaccine against malignant melanoma using monocyte-derived dendritic cells stimulated with OK-432 and PGE2 (2009)
  • Author(s): 佐藤まりも、田原秀晃, 他5名
  • Organizer: 日本癌学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-02
• [Presentation] Potent Anti-tumor Immunity and both Th1 and Th17 promotion associated with IL-23 administration (Symposium) Annual Meeting (2008)
  • Author(s): Hideaki Tahara
  • Organizer: International Society of Biological Therapy for Cancer
  • Place of Presentation: 米国San Diego
  • Year and Date: 2008-10-31