運動の開始と維持に関する脳内機構の解明

2008 Fiscal Year Annual Research Report

• Project/Area Number: 20020013
• Research Institution: Kyoto University
• Principal Investigator: 福山 秀直 Kyoto University, 医学研究科, 教授 (90181297)
• Co-Investigator(Kenkyū-buntansha): 池田 昭夫 京都大学, 医学研究科, 准教授 (90212761) ; 三國 信啓 京都大学, 医学研究科, 准教授 (60314217) ; 松本 理器 京都大学, 医学研究科, 助教 (00378754) ; 澤本 伸克 京都大学, 医学研究科, 助教 (90397547) ; 浦山 慎一 京都大学, 医学研究科, 助教 (10270729)
• Keywords: 神経科学 / 磁気記録 / 脳・神経 / 脳神経疾患

Research Abstract

1) 後部頭頂葉を含む領域に慢性硬膜下電極を留置した患者4例を対象として、自己ペースでの中心視野の指標への到達運動を課題として運動関連脳電位(MRCP)を記録し、同一上肢の単純運動課題を対照として、同時に記録した一次運動野の電位と比較した。到達運動課題では単純運動課題と比較して、頭頂葉の後部背側と頭頂間溝近傍の電極から運動開始に先行する緩電位を認めた。頭頂葉の緩電位に関しては頭頂間溝の近傍において起始潜時が早い傾向を示した。またその電位変化は同時に記録された一次運動野での電位と明らかに異なる変動を示した。以上から、ヒトの頭頂葉領域は、要素的運動よりもむしろ行為において、錐体路とは異なる活動様式で運動の準備と遂行に関わることが示唆された。この領域の障害が、要素的運動は保たれるが行為が障害される視覚性運動失調に関わっている可能性がある。2)覚醒下脳神経外科手術のために脳表電極を装着した患者を対象として、1分間の手・足関節の持続伸展中の皮質脳波-筋電図コヒーレンス解析、1Hzの手・足関節運動時のMRCP記録、を施行した。対照として皮質電気刺激での運動野マッピングの分布も調べた。コヒーレンス陽性の領域は中心溝周囲に広く分布し、9例中8例では電気刺激による陽性運動野は全電極でコヒーレンスが陽性だった。MRCP陽性領域の分布はコヒーレンスよりも狭く、8例中6例で電気刺激での陽性運動野電極全てにMRCPを認めた。以上より、一次運動野とその近傍は、単純運動の開始直前から活動することが示唆され、運動の遂行維持にはさらにその周辺に及ぶ皮質領域が筋電図に同期して活動することが示唆された。

Research Products

• [Journal Article] Negative motor seizure arising from negative motor area : is it ictal apraxia? (2009)
  • Author(s): Akio Ikeda, et.al
  • Journal Title: Epilepsia (in press)
  • Peer Reviewed
• [Journal Article] Water-diffusion slowdown in the human visual cortex on visual stimulation precedes vascular responses (2009)
  • Author(s): Kohno S, Sawamoto N, Urayama SI, Aso T, Aso K, Seiyama A, Fukuyama H, Le Bihan D
  • Journal Title: J Cereb Blood Flow Metab (in press)
  • Peer Reviewed
• [Journal Article] Correlation between Cognitive Deficits and Glucose Hypometabolism in Mild Cognitive Impairment (2009)
  • Author(s): Nishi H, Sawamoto N, Namiki C, Yoshida H, Thuy DH, Ishizu K, Hashikawa K, Fukuyama H
  • Journal Title: J Neuroimaging (in press)
  • Peer Reviewed
• [Journal Article] A novel composite targeting method using high-field magnetic resonance imaging for subthalamic nucleus deep brain stimulation (2009)
  • Author(s): Toda H, Sawamoto N, Hanakawa T, Saiki H, Matsumoto S, Okumura R, Ishikawa M, Fukuyama H, Hashimoto N
  • Journal Title: J Neurosurg (in press)
  • Peer Reviewed
• [Journal Article] Spin-echo TI-weighted Imaging of the Brain with Interleaved Acquisition and Presaturation Pulse at 3 T A Feasibility Study Before Clinical Use(1) (2009)
  • Author(s): Kasahara S, Miki Y, Mori N, Urayama SI, Kanagaki M, Fushimi Y, Maeda C, Sawamoto N, Fukuyama H, Togashi K
  • Journal Title: Acad Radiol (in press)
  • Peer Reviewed
• [Journal Article] Reduced white matter integrity correlated with cortico-subcortical gray matter deficits in schizophrenia (2009)
  • Author(s): Miyata I, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T
  • Journal Title: chizophr Res (in press)
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Imaging at 3 Testa Delineates the Optic Radiation (2009)
  • Author(s): Mori N, Miki Y, Kasahara S, Maeda C, Kanagaki M, Urayama SI, Sawamoto N, Fukuyama H, Togashi K
  • Journal Title: Invest Radiol (in press)
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of the arcuate fasciculus. A preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test (2008)
  • Author(s): Riki Matsumoto, et.al
  • Journal Title: Journal of Neurology 255 Pages: 1703-1711
  • Peer Reviewed
• [Journal Article] Cognitive deficits and striato-frontal dopamine release in Parkinson's disease (2008)
  • Author(s): Sawamoto N, Piccini P, Hotton G, Pavese N, Thielemans K, Brooks DJ
  • Journal Title: Brain 131 Pages: 1294-1302
  • Peer Reviewed
• [Journal Article] The role of the uncinate fasciculus in memory and emotional recognition in amnestic mildcognitive impairment (2008)
  • Author(s): Fujie S, Namiki C, Nishi H, Yamada M, Miyata I, Sakata D. Sawamoto N, Fukuyama H, Hayashi T, Murai T
  • Journal Title: Dement Geriatr Cogn Disord 26 Pages: 432-439
  • Peer Reviewed
• [Journal Article] Female specific anterior cingulate abnormality and its association with empathic disability in schizophrenia (2008)
  • Author(s): Fujiwara H, Shimizu M, Hirao K, Miyata J, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1728-1734
  • Peer Reviewed
• [Journal Article] Theory of mind and frontal lobe pathology in schizophrenia : a voxel-based morphometry study (2008)
  • Author(s): Hirao K, Miyata J, Fujiwara H, Yamada M, Namiki C, Shimizu M. Sawamoto N, Fukuyama H, Hayashi T, Murai T
  • Journal Title: Schizophr Res 105 Pages: 165-174
  • Peer Reviewed
• [Journal Article] The presence of multiple microbleeds as a predictor of subsequent cerebral hemorrhage in patients with moyamoya disease (2008)
  • Author(s): Kikuta K, Takagi Y, Nozaki K, Sawamoto N, Fukuyama H, Hashimoto N
  • Journal Title: Neurosurgery 62 Pages: 104-112
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of the arcuate fasciculus : a preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test (2008)
  • Author(s): Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: J Neurol 255 Pages: 1703-1711
  • Peer Reviewed
• [Journal Article] Microbleeds in moyamoya disease : susceptibility-weighted imaging versus T2*-weighted imaging at 3 Tesla (2008)
  • Author(s): Mori N, Miki Y, Kikuta K, Fushimi Y, Okada T, Urayama S, Sawamoto N, Fukuyama H, Hashimoto N, Togashi K
  • Journal Title: Invest Radiol 43 Pages: 574-579
  • Peer Reviewed
• [Presentation] 運動の視覚情報観察から準備、実行への過程 : ミラーニューロン系に関する事象関連電位の検討 (2008)
  • Author(s): 多喜純也、池田昭夫、臼井桂子、三國信啓、松本理器、寺田清人、馬場好一、長峯隆、井上有史、福山秀直、橋本信夫
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] 側頭葉底部言語野の機能および解剖的解析 : 高頻度皮質電気刺激による検討 (2008)
  • Author(s): 今村久司、松本理器、他
  • Organizer: 第42回日本てんかん学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-19
• [Presentation] Movement-related changes in human cortical activity : an input from direct cortical recording (2008)
  • Author(s): Ikeda A, Nagamine T, Matsuhashi M, Taki J
  • Organizer: The 16th International Conference on Biomagnetism
  • Place of Presentation: Sappro, Japan
  • Year and Date: 2008-08-27
• [Presentation] Somatosensory evoked magnetic fields in patients with tongue sensory deficits (2008)
  • Author(s): Maezawa H, Yoshida K, Bessho K, Matsuhashi M, Yokoyama Y, Nagamine T, Fukuyama H
  • Organizer: The 16th International Conference on Biomagnetism
  • Place of Presentation: Sappro, Japan
  • Year and Date: 2008-08-26
• [Presentation] Peri-ictal alteration of cortico-cortical excitability in focal cortical dysplasia : A CCEP study (2008)
  • Author(s): Riki Matsumoto, et.al
  • Organizer: 1st Korean and Japan Epilepsy Society Joint Symposium
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2008-06-27
• [Presentation] In vivo tracking of cortico-cortiocal connections in humans : a combined study of CCEP and probabilistic diffusion tractography (2008)
  • Author(s): Matsumoto R, Sawamoto N, Urayama S, Mikuni N, Hanakawa T, Behrens T, Ikeda A, Takahashi R, Fukuyama H
  • Organizer: 14th annual meeting for Organization of Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2008-06-18
• [Presentation] 後頭頂葉の皮質電気刺激における視覚性運動失調 : てんがん外科術前マッピングでの検討 (2008)
  • Author(s): 井内盛遠、松本理器、他
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] ヒトの前頭・頭頂葉間の皮質問ネットワーク : 機能・画像的解析による脳内回路の同定 (2008)
  • Author(s): 松本理器、他
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] Improved cerebral function in patients with intractable mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy (2008)
  • Author(s): Takaya S, Mikuni N, Mitsueda T, Taki J, Kinoshita M, Ikeda A, Fukuyama H
  • Organizer: The 60th Annual Meeting of the American Academy of Neurology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-04-17
• [Presentation] Human Parietal Reach Region : An Epicortical Field Potential Recording for Reaching (2008)
  • Author(s): Morito Inouchi, junya Taki. Takayuki Kikuchi, Takahiro Mitsueda. Riki Matsumoto. Nobuhiro Mikuni, Lewis Wheaton. Mark Hallett, Hidenao Fukuyama, Hiroshi Shibasakt, Ryosuke Takahashi. Akio Ikeda
  • Organizer: The 60th Annual Meeting of the American Academy of Neurology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-04-15