CONNECTION SELECTIVITY IN CEREBRAL CIRCUITRY

2009 Fiscal Year Final Research Report

• Project/Area Number: 20020032
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: KAWAGUCHI Yasuo National Institute for Physiological Sciences, 大脳皮質機能研究系, 教授 (40169694)
• Project Period (FY): 2008 – 2009
• Keywords: 大脳皮質 / 局所回路 / 錐体細胞 / 介在細胞 / GABA / 層構造 / シナプス結合 / 徐波

Research Abstract

Elucidation of neocortical organization principles is crucial for understanding the function of the cerebral cortex. We quantitatively identified excitatory pyramidal and GABAergic nonpyramidal cell subtypes. We found that the neuron subtypes exhibited selective connectivity and that GABAergic cells discharged during the local and global rhythms. Thus, the local synaptic organization and firing activity in the neocortex are specified according to global inter-regional circuits and their oscillatory interaction.

Research Products

• [Journal Article] Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections (2009)
  • Author(s): Kubota Y, Hatada S, Kawaguchi Y
  • Journal Title: Front. Neural Circuits 3 Pages: 4
  • Peer Reviewed
• [Journal Article] Cortical inhibitory cell types differentially form intralaminar and interlaminar subnetworks with excitatory neurons (2009)
  • Author(s): Otsuka T, Kawaguchi Y
  • Journal Title: J Neurosci 29 Pages: 10533-10540
  • Peer Reviewed
• [Journal Article] Two distinct activity patterns of fast-spiking interneurons during neocortical UP-states (2008)
  • Author(s): Puig MV, Ushimaru M, Kawaguchi Y
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 8428-8433
  • Peer Reviewed
• [Journal Article] Firing-pattern dependent specificity of cortical excitatory feed-forward subnetworks (2008)
  • Author(s): Otsuka T, Kawaguchi Y
  • Journal Title: J. Neurosci. 28 Pages: 11186-11195
  • Peer Reviewed
• [Journal Article] Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats (2008)
  • Author(s): Uematsu M, Hirai Y, Karube F, Ebihara S, Kato M, Abe K, Obata K, Yoshida S, Hirabayashi M, Yanagawa Y, Kawaguchi Y
  • Journal Title: Cereb Cortex 18 Pages: 315-330
  • Peer Reviewed
• [Presentation] Cortical Neuron Diversity and Local Connection Selectivity (2010)
  • Author(s): Yasuo Kawaguchi
  • Organizer: 第56回NIBB CONFERENCE " Neocortical Organization "
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-12
• [Presentation] 大脳皮質の階層構造 (2009)
  • Author(s): 川口泰雄
  • Organizer: 自然科学研究機構連携プロジェクト「自然科学における階層と全体」平成21年度シンポジウム
  • Place of Presentation: 熱海
  • Year and Date: 2009-12-24
• [Presentation] Local connectivity of cortical projection neurons depends on their extracortical targets. Construction and Reconstruction of the Brain (2009)
  • Author(s): Yasuo Kawaguchi
  • Organizer: 大阪大学大学院生命機能研究科グローバルCOEプログラム
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-09
• [Presentation] 大脳皮質ニューロンの結合選択性と発火特異性 (2009)
  • Author(s): 川口泰雄
  • Organizer: 第32回日本神経科学大会時実賞受賞記念講演
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Cortical GABAergic and Pyramidal Cell Subtypes (2009)
  • Author(s): Yasuo Kawaguchi
  • Organizer: Gordon Research Conferense
  • Place of Presentation: Waterville, ME (USA)
  • Year and Date: 2009-07-28
• [Presentation] 大脳皮質のニューロン多様性と特異的振動 (2008)
  • Author(s): 川口泰雄
  • Organizer: 第39回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-08
• [Book] 大脳皮質内興奮性回路の機能分化. "ブレインサイエンスレビュー2009"(伊藤正男・川合述史編) (2009)
  • Author(s): 川口泰雄
  • Total Pages: 181-205
  • Publisher: クバプロ
• [Book] 生体の科学(大脳皮質における振動生成と結合特異性) (2009)
  • Author(s): 川口泰雄
  • Total Pages: 31-38
• [Book] The New Encyclopedia of Neuroscience(ed Squire L, Structures and Circuits: Cerebral Cortex, Inhibitory cells.) (2008)
  • Author(s): Kawaguchi Y, Karube F
  • Publisher: Elsevier
• [Remarks]
  • URL: http://www.nips.ac.jp/circuit/