2010 Fiscal Year Final Research Report
New approach for health maintenanceand disease control by modification of inhaled air composition
| Project/Area Number |
20200021
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
General human life sciences
Hygiene
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| Research Institution | Chubu University |
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Principal Investigator |
ICHIHARA Masatoshi Chubu University, 生命健康科学部, 教授 (00314013)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Tamaki 中部大学, 生命健康科学部, 助手 (90392018)
MURAKUMO Yoshiki 名古屋大学, 大学院・医学系研究科, 准教授 (40324438)
MASUDA Akio 名古屋大学, 大学院・医学系研究科, 助教 (10343203)
YONEDA Makoto 福井大学, 医学部, 准教授 (70270551)
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| Research Collaborator |
OHNO Kinji 名古屋大学, 大学院・医学系研究科, 教授 (80397455)
ITO Masafumi 岐阜県国際バイオ研究所, 部長 (80393114)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 住環境 / 分子状水素 / 活性酸素 / 酸化ストレス |
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| Research Abstract |
Recent studies demonstrated that molecular hydrogen functions as a novel antioxidant. We examined whether molecular hydrogen attenuates disease progression using model animals such as Parkinson disease, allergic reaction, liver damage by bacterial toxin and others and found that molecular hydrogen is effective for a wide variety of diseases including inflammatory diseases in which oxidative stress is not a major cause of the pathogenesis. We also found that hydrogen slightly extended the lifespan in C. elegans under 60% oxygen condition. DNA microarray analysis revealed that short-lasting hydrogen exposure by hydrogen-rich water induced more significant change in gene expression in the liver tissue. These results suggest that intermittent administration of hydrogen in living environment may serve as a new approach for health maintenance.
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[Journal Article] Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.2011
Author(s)
Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M.
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Journal Title
Mol Biol Cell. 22(6)
Pages: 736-747
Peer Reviewed
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[Journal Article] ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells : the role of COUP-TFI.2010
Author(s)
Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, Ichihara M, Takagi A, Kojima T, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Suzuki M, Banno Y, Nozawa Y, Murate T.
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Journal Title
J Neurochem. 112(2)
Pages: 511-520
Peer Reviewed
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[Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.2009
Author(s)
Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K.
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Journal Title
Neurosci Lett. 453(2)
Pages: 81-85
Peer Reviewed
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[Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009
Author(s)
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.
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Journal Title
Neuron. 63(6)
Pages: 774-787
Peer Reviewed
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[Journal Article] Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice.2008
Author(s)
Hasegawa T, Enomoto A, Kato T, Kawai K, Miyamoto R, Jijiwa M, Ichihara M, Ishida M, Asai N, Murakumo Y, Ohara K, Niwa Y, Goto H, Takahashi M.
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Journal Title
Oncogene. 27(43)
Pages: 5684-5695
Peer Reviewed
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[Presentation] Adeno-associated virus serotype 8-mediated targeting of asymmetric acetylcholinesterase to the synaptic basal lamina at the neuromuscular junction.2008
Author(s)
Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K.
Organizer
The 38th Annual Meeting, Society for Neuroscience.
Place of Presentation
Washington D. C., USA
Year and Date
20081115-20081119
