2010 Fiscal Year Final Research Report
Chemical biology aimed at the development of new thrombolytics
| Project/Area Number |
20200037
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
Drug development chemistry
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| Research Institution | Akita University |
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Principal Investigator |
KOIZUMI Yukio 秋田大学, 大学院・医学系研究科, 助教 (80353465)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Kenichiro 北里大学, 薬学部, 助教 (30321649)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ケミカルバイオロジー / 血栓溶解 / 微生物二次代謝産物 |
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| Research Abstract |
Structure-activity relationships of cyclic pentapeptide, malformin A1 (MA1), showed that the formation of intramolecular disulfide bond and the existence of hydrophobic side-chains were essential for the enhancement of fibrinolysis by MA1. In addition, the correlation between enhancement of fibrinolysis and cytotoxicity was not observed, suggesting that the separation of each activity is possible. The studies using radioisotope-labeling and fluorescence-labeling revealed the intracellular localization of MA1. Moreover, malformin-affinity beads detected 65 kDa and 22 kDa cellular malformin-high affinity proteins.
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[Journal Article] Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides2009
Author(s)
Yanagimoto C, Harada M, Kumemura H, Koga H, Kawaguchi T, Terada K, Hanada S, Taniguchi E, Koizumi Y, Koyota S, Ninomiya H, Ueno K, Sugiyama T, Sata M.
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Journal Title
Exp. Cell Res.
Volume: 315
Pages: 119-126
DOI
Peer Reviewed
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