2010 Fiscal Year Final Research Report
Interdisciplinary study for the elucidation of metalloenzyme reaction mechanism in dioxygen activation and highly efficient molecular catalyst creation
| Project/Area Number |
20200050
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
Inorganic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
LIU Jin-Gang Kyushu University, 先導物質化学研究所, 特任准教授 (70380540)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Takehiro 九州大学, 先導物質化学研究所, 助教 (70509950)
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| Co-Investigator(Renkei-kenkyūsha) |
OGURA Takashi 兵庫県立大学, 生命理学研究科, 教授 (70183770)
YODA Yoshitaka (財)高輝度光科学研究センター, 主幹研究員 (90240366)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 酵素 / モデル化 / 生体分子 / 生体機能化学 / 生物無機化学 / 分子触媒化学 / 酸化触媒 |
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| Research Abstract |
The O_2 activation/reduction reaction is one of the most important reactions involved in both of life processes and in energy converting systems such as fuel cells. This project is intended to further elucidation of the O_2 activation mechanism of metalloenzymes and creation of highly efficient molecular catalyst for O_2-reduction. Using well designed heme enzyme chemical models, we have successfully captured and fully characterized key intermediates involved in the O_2-activation processes of heme-containing enzymes by various kinds of spectroccopies as well as quantum chemical calculations. These studies have contributed significantly to the understanding of the mechanism of dioxygen activation by heme enzymes and their models. The prepared non-precious-metal catalysts will have prosperous applications as the cathode oxygen reduction reaction (ORR) catalysts in fuel cells.
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