2010 Fiscal Year Final Research Report
Development and Application of Methods for Catalytic Asymmetric Synthesis of Planar-Chiral Metallocene Complexes
| Project/Area Number |
20200051
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
Organic industrial materials
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| Research Institution | Hokkaido University |
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Principal Investigator |
OGASAWARA Masamichi Hokkaido University, 触媒化学研究センター, 准教授 (70301231)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メタロセン / 不斉合成 / 面不斉 / 均一系触媒 / 有機金属錯体 / 遷移金属触媒 / 光学活性 / メタセシス |
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| Research Abstract |
As shown in various planar-chiral metallocenylphosphine ligands, transition-metal complexes with planar chirality are useful chiral templates and have been utilized in asymmetric synthesis as chiral catalysts and chiral reagents. In spite of their usefulness, catalytic asymmetric reactions of preparing such planar-chiral compounds have bee extremely rare. In this research project, we have succeeded to develop various novel protocols of catalytically preparing planar-chiral metallocene derivatives in high enantiomeric purity. The methods we have developed include kinetic resolution of racemic planar-chiral metallocenes as well as asymmetric desymmetrization of planar-prochiral phosphaferrocenes. We have also demonstrated that our methods can be applicable to kinetic resolution of planar-chiral (η^6-arene)chromium complexes, indicating potential versatility of the protocols.
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[Journal Article] Preparation of Osmium- 5-Phospholide Complexes and Their Reactions with Acyl Electrophiles : C=O Bond Cleavage and C-C Bond Formation within Metal-Coordination Sphere2011
Author(s)
Ogasawara, M., Shintani, M., Watanabe, S., Sakamoto, T., Nakajima, K., Takahashi, T.
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Journal Title
Organometallics 30
Pages: 1487-1492
Peer Reviewed
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[Journal Article] Unusual Transposition of Allenic Framework in Intramolecular Cyclization of Acetal-Tethered (Allenylmethyl)silanes2009
Author(s)
Ogasawara, M., Okada, A., Murakami, H., Watanabe, S., Ge, Y., Takahashi, T.
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Journal Title
Org.Lett. 11
Pages: 4240-4243
Peer Reviewed
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[Journal Article] Ring-Closing Metathesis within Chromium-Coordination Sphere : Facile Access to Phosphine-Chelate (π-Arene)chromium Complexes
Author(s)
Ogasawara, M., Wu, W.-Y., Arae, S., Morita, T., Watanabe, S., Takahashi, T., Kamikawa, K.
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Journal Title
J.Organomet.Chem. in press
Peer Reviewed
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