2010 Fiscal Year Final Research Report

Membrane morphology -An attempt to reconstitute the cristae structure in liposome-

Research Project

Project/Area Number	20200058
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
Allocation Type	Single-year Grants
Research Field	Morphology/Structure Cell biology
Research Institution	Kyushu University
Principal Investigator	OKA Toshihiko Kyushu University, 医学研究院, 准教授 (40263321)
Project Period (FY)	2008 – 2010
Keywords	メンブレンモルフォロジー / クリステ構造
Research Abstract	Biomembranes are various in form, and the diversity of the shapes of biomembranes are critical for cell viability. To understand the function of the shapes in intra-and inter-cellular activities, we attempted to reconstitute in vitro the cristae structure, an invaginated inner membrane of mitochondria, onto liposomes. Using a recombinant protein of LETM1, a mitochondrial protein required for maintenance of the cristae structure, multiple membrane invagination was successfully formed on liposomes.