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2010 Fiscal Year Final Research Report

The role of sphingolipids in hepatitis C virus replication and its alteration of spingolipids metabolism.

Research Project

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Project/Area Number 20200067
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Virology
Cell biology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

HIRATA Yuichi  Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員 (50439452)

Co-Investigator(Kenkyū-buntansha) YASUI Fumihiko  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (40399473)
MUNAKATA Tsubasa  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (50420237)
SEKIGUCHI Satoshi  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (10462780)
Co-Investigator(Renkei-kenkyūsha) KOHARA Michinori  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10250218)
TAGUCHI Ryo  東京大学, 医学(系)研究科(研究院), 客員教授 (20080210)
Project Period (FY) 2008 – 2010
Keywords分子・生体膜
Research Abstract

We demonstrated that HCV altered sphingolipids metabolism, performing the analysis, using MS spectrometer, of the sphingolipids content in uninfected humanized chimeric mice, HCV infected chimeric mice, and HCV infected chimeric mice treated with the inhibitor of sphingolipids biosynthesis. Furthermore, specific sphingomyelin molecular species contributed to HCV replication, and these sphigomyelin molecular species activated the polymerase of HCV.

  • Research Products

    (34 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (24 results) Remarks (1 results)

  • [Journal Article] Sphingomyelin activates hepatitis C virus RNA polymerease in a genotype specific manner.2010

    • Author(s)
      Weng L., Hirata Y., Arai M., Kohara M., Wakita T., Watashi K., Shimotohno K., He Y., Zhong J., Toyoda T.
    • Journal Title

      J Virol. 84(22)

      Pages: 1761-1770

    • Peer Reviewed
  • [Journal Article] Suppression of hepatitis C virus (HCV) with serine palmitoyltransferase inhibitor.2010

    • Author(s)
      Hirata Y., Sudoh M., Kohara M.
    • Journal Title

      Yakugaku Zasshi 130(2)

      Pages: 157-161

  • [Journal Article] スフィンゴ脂質合成阻害薬のC型肝炎ウイルスに対する薬理作用2010

    • Author(s)
      平田雄一、小原道法
    • Journal Title

      肝胆膵 61(増刊号)

      Pages: 216-222

  • [Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.2010

    • Author(s)
      Takano T., Tsukiyama-Kohara K., Hayashi M., Hirata Y., Satoh M., Tateno C., Hayashi Y., Hishima T., Funata N., Sudo M., Kohara M.
    • Journal Title

      J.Hepatology (in press)

    • Peer Reviewed
  • [Journal Article] Pathogenesis of hepatitis C virus infection in Tupaia belangeri.2010

    • Author(s)
      Amako Y., Tsukiyama-Kohara K., Katsume A., Hirata Y., Sekiguchi S., Tobita Y., Hayashi Y., Hishima T., Funata N., Yonekawa .H, Kohara M.
    • Journal Title

      J Virol. 84(1)

      Pages: 303-311

    • Peer Reviewed
  • [Journal Article] Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase.2009

    • Author(s)
      Nishimura T., Kohara M., Izumi K., Kasama Y., Hirata Y., Huang Y., Shuda M., Mukaidani C., Takano T., Tokunaga Y., Nuriya H., Satoh M., Saito M., Kai C., Tsukiyama-Kohara K.
    • Journal Title

      J Biol Chem 284(52)

      Pages: 36442-36452

  • [Journal Article] Disruption of IFN signaling and HCV synergistically enhance lymphoproliferation through type II CD95 and interleukins.2009

    • Author(s)
      Machida K., Tsukiyama-Kohara K., Sekiguchi S., Seike E., Tone S., Hayashi Y., Kasama Y., Shimizu M., Takahashi H., Taya C., Yonekawa H., Tanaka N., Kohara M.
    • Journal Title

      Gastroenterology 137(1)

      Pages: 285-296

    • Peer Reviewed
  • [Journal Article] C型肝炎ウイルスの持続感染機構と病原性2009

    • Author(s)
      関口敏、飛田良美、小原道法
    • Journal Title

      メディカル・サイエンス・ダイジェスト 35(6)

      Pages: 14-17

  • [Journal Article] Suppression of hepatitis C virus with the reagent targetting host factors.2008

    • Author(s)
      Hirata Y., Sudoh M., Kohara M.
    • Journal Title

      Uirusu 58(2)

      Pages: 207-213

  • [Presentation] 脂肪酸合成酵素を介したパルミチン酸によるC型肝炎ウイルスの複製制御2010

    • Author(s)
      棟方翼、野本明男、小原道法
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20101107-20101109
  • [Presentation] A Interferon lambda plays a critical role on antiviral response by hepatotropic inducer of innate immunity in human hepatocyte.2010

    • Author(s)
      Hirata Y., Nakagawa S., Tokunaga Y., Tanaka Y., Mizokami M., Inoue K., Kohara M.
    • Organizer
      The 61th Annual Meeting of the American Association for the Study of the Liver Disease
    • Place of Presentation
      Boston, USA
    • Year and Date
      20101029-20101102
  • [Presentation] スフィンゴ脂質合成阻害剤の抗HCV薬理作用2010

    • Author(s)
      平田雄一、須藤正幸、小原道法
    • Organizer
      第18回消化器病学会関連週間(JDDW2010)
    • Place of Presentation
      横浜
    • Year and Date
      20101013-20101016
  • [Presentation] IFNλを強力に誘導する核酸/リポソーム製剤の同定とその抗HCV効果2010

    • Author(s)
      平田雄一、井上和明、小原道法
    • Organizer
      第18回消化器病学会関連週間(JDDW2010)
    • Place of Presentation
      横浜
    • Year and Date
      20101013-20101016
  • [Presentation] A newly synthesized serine palmitoyltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus via hindering host-virus interactions.2010

    • Author(s)
      Hirata Y., Sudoh M., Tokunaga Y., Tobita Y., Kohara M.
    • Organizer
      The 17th International Meeting on Hepatitis C virus and related viruses
    • Place of Presentation
      Yokohama
    • Year and Date
      20100910-20100914
  • [Presentation] Palmitate regulates HCV replication.2010

    • Author(s)
      Munakata T., Nomoto A., Kohara M.
    • Organizer
      17th International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      横浜
    • Year and Date
      20100910-20100914
  • [Presentation] Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.2010

    • Author(s)
      Yasui F., Sudoh M., Kohara M.
    • Organizer
      17th International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      横浜
    • Year and Date
      20100910-20100914
  • [Presentation] Hepatitis C virus altered the sphingolipids metabolism for better environment on its replication.2010

    • Author(s)
      Hirata Y., Ikeda K., Sudoh M., Tokunaga Y., Taguchi R., Kohara M.
    • Organizer
      KEYSTONE SYMPOSIA Bioactive Lipids
    • Place of Presentation
      Kyoto
    • Year and Date
      20100606-20100611
  • [Presentation] A newly synthesized serine palmytoiltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus via hindering host-virus interactions.2009

    • Author(s)
      Hirata Y., Sudoh M., Tokunaga Y., Tobita Y., Kohara M.
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-20091212
  • [Presentation] A newly synthesized serine palmytoiltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus via hindering host-virus interactions.2009

    • Author(s)
      Hirata Y., Sudoh M., Tokunaga Y., Tobita Y., Kohara M.
    • Organizer
      60th Annual Meeting of the American Association for the study of the liver disease.
    • Place of Presentation
      Boston, USA
    • Year and Date
      20091030-20091103
  • [Presentation] 新規SPT阻害剤NA808の抗HCV効果2009

    • Author(s)
      平田雄一、須藤正幸、池田和貴、徳永優子、飛田良美、田口良、小原道法
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京
    • Year and Date
      20091025-20091027
  • [Presentation] NA 808 has the strong effect to hepatitis C virus and in vivo.2009

    • Author(s)
      Hirata Y., Sudoh M., Tokunaga Y., Tobita Y., Tsukuda T., Kohara M.
    • Organizer
      16th Internationl Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Nice, France
    • Year and Date
      20091003-20091007
  • [Presentation] Anti-hepatitis C virus activity of cyclin-dependent kinase inhibitors.2009

    • Author(s)
      Munakata T., Inada M., Nomoto A., Kohara M.
    • Organizer
      16th Internationl Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Nice, France
    • Year and Date
      20091003-20091007
  • [Presentation] A newly synthesized serine palmitoyltransferase inhibitor, NA808, has the strong effect to hepatitis C virus in vitro and in vivo.2009

    • Author(s)
      Hirata Y., Sudoh M., Tsukuda T., Ikeda K., Taguchi R., Kohara M.
    • Organizer
      44th Annual Meeting of the European Association for the study of the liver
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      20090422-20090426
  • [Presentation] Interphase cyclin-dependent kinases regulate hepatitis C virus replication.2009

    • Author(s)
      Munakata T., Inada M., Nomoto A., Kohara M
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
  • [Presentation] サイクリン依存性リン酸化酵素阻害剤によるC型肝炎ウイルスの複製制御2009

    • Author(s)
      Munakata T.,Inada M., Nomoto A., Kohara M.
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
  • [Presentation] スフィンゴミエリンはC型肝炎ウイルス複製に必要な脂質成分である2008

    • Author(s)
      平田雄一、池田和貴、須藤正幸、楳原琢也、飛田良美、田口良、小原道法
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081209-20081212
  • [Presentation] HCV遺伝子組換えワクチニアウイルスの治療ワクチン効果2008

    • Author(s)
      関口敏、千代智子、飛田良美、松原明弘、保富康宏、水野喬介、村井深、小原道法
    • Organizer
      第12回日本ワクチン学会学術集会
    • Place of Presentation
      熊本
    • Year and Date
      20081108-20081109
  • [Presentation] SPT阻害剤によるHCV複製阻害機序の解析2008

    • Author(s)
      平田雄一、須藤正幸、池田和貴、楳原琢也、飛田良美、田口良、小原道法
    • Organizer
      第56回ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      20081026-20081028
  • [Presentation] 新規HCV持続感染モデルマウスの作製とその病態解析2008

    • Author(s)
      関口敏、飛田良美、千代智子、小原道法
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      20081026-20081028
  • [Presentation] Presistent infection of Hepatitis C virus to get over the acquired immunity system2008

    • Author(s)
      Sekiguchi S., Tobita Y., Kohara M.
    • Organizer
      第8回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫
    • Year and Date
      20080907-20080911
  • [Presentation] Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model.2008

    • Author(s)
      Hirata Y., Umehara T., Sudoh M. Kohara M.
    • Organizer
      XIV International Congress of Virology
    • Place of Presentation
      Istanbul
    • Year and Date
      20080810-20080815
  • [Presentation] Serine Palmitoyltransferase Inhibitor Suppresses HCV Replication in a Mouse Model.2008

    • Author(s)
      Hirata Y. Umehara T., Sudoh M., Yasui F., Kohara M.
    • Organizer
      21th International Conference on Antiviral Research
    • Place of Presentation
      Montreal
    • Year and Date
      20080413-20080417
  • [Presentation] セリンパルミトリルトランスフェラーゼ(SPT)阻害剤のin vitro及びin vivoにおけるHCV複製抑制効果の検討2008

    • Author(s)
      平田雄一、須藤正幸、小原道法
    • Organizer
      第16回日本消化器病学会関連週間(JDDW2008)
    • Place of Presentation
      東京
    • Year and Date
      20080000
  • [Remarks] ホームページ等

    • URL

      http://www.igakuken.or.jp/

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Published: 2012-02-13   Modified: 2016-04-21  

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