Therapeutic application of growth hormone and IGF-I for nonalcoholic steatohepatitis

2010 Fiscal Year Final Research Report

• Project/Area Number: 20200079
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology; General pharmacology
• Research Institution: Kobe University
• Principal Investigator: TAKAHASHI Yutaka Kobe University, 医学研究科, 講師 (70301281)
• Project Period (FY): 2008 – 2010
• Keywords: 内分泌学 / 生理活性物質

Research Abstract

We have reported a case of adult growth hormone deficiency (AGHD) accompanied with nonalcoholic steatohepatitis (NASH), in which GH replacement therapy drastically ameliorated NASH. Then, we have analyzed the prevalence of NAFLD/NASH in the patients with AGHD and found that NAFLD/NASH are frequently observed in AGHD and GH replacement therapy improved these conditions. Based on these results, we explored whether GH or IGF-I ameliorates general NASH using animal model. Interestingly, we found that GH particularly IGF-I ameliorated steatosis and fibrosis in the liver of the animal model, implicating a therapeutic application of IGF-I for general NASH.

Research Products

• [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes (2011)
  • Author(s): Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Journal Title: Endocrinology 152 Pages: 912-21
• [Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans (2011)
  • Author(s): Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
  • Journal Title: J Clin Invest 121 Pages: 113-9
• [Journal Article] A case of primary aldosteronism caused by multiple adrenocortical macronodules (2011)
  • Author(s): Hashimoto N, Kawamura Y, Nakamura T, Murawaki A, Nishiumi T, Hirota Y, Sakagushi K, Kurahashi T, Miyake H, Fujisawa M, Sasano H, Takahashi Y
  • Journal Title: Intern Med 50 Pages: 585-90
• [Journal Article] Sano S Circulating level of chemerin is upregulated in psoriasis. (2010)
  • Author(s): Nakajima H, Nakajima K, Nagano Y, Yamamoto M, Tarutani M, Takahashi M, Takahashi Y
  • Journal Title: J Dermatol Sci 60 Pages: 45-47
• [Journal Article] Okimura W194XProp1 and S156insTProp1, both of which have intact DNA-binding domain, show a different DNA-binding activity to the Prop1-binding element in human Pit-1 gene. (2010)
  • Author(s): Shibahara H, Ikeshita N, Sugiyama Y, Toda K, Yamamoto D, Herningtyas EH, Maki T, Kubota E, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K
  • Journal Title: Mol Cell Endocrinol 323 Pages: 167-171
• [Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes. (2010)
  • Author(s): Fukuoka H, Iida K, Nishizawa H, Imanaka M, Takeno R, Iguchi G, Takahashi M, Okimura Y, Kaji H, Chihara K, Takahashi Y.
  • Journal Title: Growth Horm IGF Res 20 Pages: 212-219
• [Journal Article] Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats. (2010)
  • Author(s): Yamamoto D, Maki T, Herningtyas EH, Ikeshita N, Shibahara H, Sugiyama Y, Nakanishi S, Iida K, Iguchi G, Takahashi Y, Kaji H, Chihara K, Okimura Y
  • Journal Title: Muscle Nerve 41 Pages: 819-827
• [Journal Article] A case of hypothalamic panhypopituitarism with empty sella syndrome: case report and review of the literature. (2009)
  • Author(s): Komada H, Yamamoto M, Okubo S, Nagai K, Iida K, Nakamura T, Hirota Y, Sakaguchi K,Kasuga M, Takahashi Y.
  • Journal Title: Endocrine J 56 Pages: 585-589
• [Journal Article] Difference between Japanese and Caucasian populations in the allelic frequency of growth hormone receptor polymorphism. (2009)
  • Author(s): Iida K, Takahashi Y, Kaji H, Okimura Y, Nose O, Chihara K.
  • Journal Title: J Pediatr Endocrinol Metab 22 Pages: 41-6
• [Journal Article] 二次性徴が欠如し30歳で発見された下垂体茎断裂症候群の1例 (2009)
  • Author(s): 中村友昭, 村脇あゆみ, 西海智子, 橋本尚子, 廣田勇士, 梶博史, 坂口一彦, 小川渉, 清野進, 高橋裕
  • Journal Title: 日本内分泌学会雑誌 85 Pages: 30-32
• [Journal Article] 症例下垂体性TSH単独分泌不全症を合併した1型糖尿病の1例 (2009)
  • Author(s): 村脇あゆみ, 飯田啓二, 高橋裕
  • Journal Title: 内科 103(4) Pages: 812-815
• [Journal Article] Identification and analysis of Prop1-binding sites in human Pit-1 gene. (2008)
  • Author(s): Ikeshita N, Kawagishi M, Shibahara H, Toda K, Yamashita T, Yamamoto D, Sugiyama Y, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y.
  • Journal Title: Endocrinology 149 Pages: 5491-9
• [Journal Article] Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line. (2008)
  • Author(s): Herningtyas EH, Okimura Y, Handayaningsih AE, Yamamoto D, Maki T, Iida K, Takahashi Y, Kaji H, Chihara K.
  • Journal Title: Biochim Biophys Acta. 1780 Pages: 1115-20
• [Journal Article] Diverse splicing abnormality caused by a homozygous mutation in the thiazide-sensitive sodium-chloride cotransporter gene in a patient with Gitelman's syndrome. (2008)
  • Author(s): Iida K, Nozu K, Takahashi Y, Okimura Y, Kaji H, Matsuo M, Chihara K.
  • Journal Title: Am J Kidney Dis. 51 Pages: 1077-78
• [Journal Article] Growth hormone stimulates mechano growth factor expression and activates myoblast transformation in C2C12 cells. (2008)
  • Author(s): Imanaka M, Iida K, Murawaki A, Nishizawa H, Fukuoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K.
  • Journal Title: Kobe J Med Sci. 54 Pages: E46-54
• [Journal Article] Low Serum IGF-I/GH Ratio Is Associated with Abnormal Glucose Tolerance in Acromegaly. (2008)
  • Author(s): Fukuoka H, Takahashi Y, Iida K, Kudo T, Nishizawa H, Imanaka M, Takeno R, Iguchi G, TakahashI K, Okimura Y, KajI H, Chihara K.
  • Journal Title: Hormone Research 69 Pages: 165-71
• [Journal Article] Leukemia inhibitory factor regulates trophoblast giant cell differentiation via JAK1-Stat3-SOCS3 pathway. (2008)
  • Author(s): Takahashi Y, Takahashi M, Carpino N, Jou ST, Chao JR, Tanaka S, Shigeyoshi Y, Parganas E, Ihle JN.
  • Journal Title: Mol Endocrinology 22 Pages: 1673-1088
• [Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle specific ubiquitin ligases, Atrogin-1 and MuRF1. (2008)
  • Author(s): Yamamoto D, Ikeshita N, Tasaki H, Herningtyas EH, Toda K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
  • Journal Title: Life Sci 82 Pages: 460-466
• [Journal Article] 千原和夫 Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes (2008)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K
  • Journal Title: FEBS letters 582 Pages: 573-578
• [Journal Article] Involvement of mmPOU(Brn-5), a class of IV POU protein, in the gene expression of Pit-1 as well as PRL. (2008)
  • Author(s): Toda K, Yamamoto D, Fumoto M, Ikeshita N, Herningtyas EH, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y.
  • Journal Title: Mol Cell Endocrinol 280(1-2) Pages: 20-9
• [Journal Article] Hepatic failure and enhanced oxidative stress in mitochodrial diabetes (2008)
  • Author(s): Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K.
  • Journal Title: Endocr J. 55 Pages: 509-514
• [Journal Article] 先端巨大症における高トリグリセライド血症は耐糖能と血清GH値に関連する (2008)
  • Author(s): 福岡秀規, 高橋裕, 工藤工, 村脇あゆみ, 西沢衡, 今中真理, 竹野亮子, 高橋路子, 井口元三, 高橋健太郎, 飯田啓二, 置村康彦, 加治秀介, 千原和夫
  • Journal Title: 日本内分泌学会雑誌 84 Pages: 120-122
• [Journal Article] ミトタンの使用中に甲状腺機能低下症の増悪を認めた周期性クッシング病の一例 (2008)
  • Author(s): 村脇あゆみ, 高橋裕, 内藤純子, 飯田啓二, 廣田勇士, 坂口一彦, 福岡秀規, 今中真理, 西沢衛, 春日雅人
  • Journal Title: 日本内分泌学会雑誌 83(4)
• [Presentation] 成人GH分泌不全症をきたす新たな疾患概念-後天性GH,PRL,TSH欠損症(スポンサードセッション) (2011)
  • Author(s): 高橋裕
  • Organizer: 第20回臨床内分泌代謝Update(招待講演)
  • Place of Presentation: 札幌
  • Year and Date: 20110000
• [Presentation] 成人GHDの合併症としてのNAFLD/NASH -トランジションに関する問題点-(シンポジウム) (2011)
  • Author(s): 高橋裕
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌
  • Year and Date: 20110000
• [Presentation] 新たな多腺性自己免疫症候群:抗PIT-1自己抗体と関連した後天性GH、PRL、TSH欠損症 (2011)
  • Author(s): 高橋裕
  • Organizer: 第6回KOPEM-MDC(慶応大学医学部セミナー)(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 20110000
• [Presentation] 下垂体機能低下症をきたす新たな疾患概念、後天性GH、PRL、TSH欠損症 (2011)
  • Author(s): 高橋裕
  • Organizer: 第5回長崎間脳下垂体疾患カンファレンス(招待講演)
  • Place of Presentation: 長崎
  • Year and Date: 20110000
• [Presentation] Adult growth hormone deficiency and nonalcoholic steatohepatitis. (2010)
  • Author(s): (Symosium) Takahashi Y
  • Organizer: The 51^<st> Annual Meeting of the Japan Diabetes Society, International Satellite Symposium (The 5^<th> I Fope Symposium)
  • Year and Date: 20100008
• [Presentation] Novel syndrome of growth hormone deficiency : adult combined GH, PRL and TSH deficiency associated with circulating anti-PIT-1 antibody. (2010)
  • Author(s): Takahashi Y
  • Organizer: HypoCCS meeting
  • Place of Presentation: Vienna
  • Year and Date: 20100000
• [Presentation] Novel syndrome of growth hormone deficiency: adult combined GH, PRL and TSH deficiency associated with circulating anti-PIT-1 antibody. (2010)
  • Author(s): Takahashi Y
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100000
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes. (2010)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100000
• [Presentation] IGF-1 induces cellular senescence via reactive oxygen species in vascular smooth muscle cells. (2010)
  • Author(s): Handayaningsih AE, Iguchi G, Fukuoka H, Nishizawa H, Yamamoto M, Herningtyas H, Takahashi M, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100000
• [Presentation] GH and IGF-□ameliorate inflammation and fibrosis in nonalcoholic steatohepatitis mouse model. (2010)
  • Author(s): Nishizawa H, Iguchi G, Takahashi M, Yamamoto M, Handayaningsih AE, Kitazawa R, Okimura Y, Kaji H, Kitazawa S, Hayashi Y, Chihara K, Seino S, Takahashi Y
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100000
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes. (2010)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Organizer: The Fifth International Congress of the GRS and the IGF
  • Place of Presentation: Society NY
  • Year and Date: 20100000
• [Presentation] 寿命調節機構 (2010)
  • Organizer: オーバービュー(シンポジウム)GH/IGF-I & Longevity Meeting 2010(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 20100000
• [Presentation] 脳神経外科疾患と成人GH分泌不全症- QOLと合併症を改善するために重要なこと-(特別講演)播磨 (2010)
  • Author(s): 高橋裕
  • Organizer: 下垂体機能低下症学術講演会(招待講演)
  • Place of Presentation: 姫路
  • Year and Date: 20100000
• [Presentation] 内分泌代謝疾患における精神症状(イブニングセミナー) (2010)
  • Author(s): 高橋裕
  • Organizer: 第7回日本うつ病学会総会(招待講演)
  • Place of Presentation: 金沢
  • Year and Date: 20100000
• [Presentation] 成人GH分泌不全症の新たな病態(特別講演) (2010)
  • Author(s): 高橋裕
  • Organizer: 成人成長ホルモン分泌不全症学術講演会(招待講演)
  • Place of Presentation: 大阪
  • Year and Date: 20100000
• [Presentation] インスリン治療歴のある患者におけるインスリン抗体結合率とScatchard解析の検討 (2010)
  • Author(s): 西海智子, 廣田勇士, 隅田健太郎, 神野歩, 有村愛子, 橋本尚子, 井口元三, 梶博史, 坂口一彦, 高橋裕, 清野進, 小川渉
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] 糖尿病合併妊娠および妊娠糖尿病症例の検討 (2010)
  • Author(s): 西海智子, 廣田勇士, 隅田健太郎, 神野歩, 有村愛子, 橋本尚子, 井口元三, 梶博史, 坂口一彦, 高橋裕, 清野進, 小川渉
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] 1型糖尿病患者におけるインスリン持続皮下注入療法(CSII)の検討 (2010)
  • Author(s): 神野歩, 廣田勇士, 隅田健太郎, 有村愛子, 西海智子, 橋本尚子, 井口元三, 梶博史, 坂口一彦, 高橋裕, 清野進, 小川渉
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] 多発限局性脂肪沈着をきたした悪性インスリノーマ微小肝転移性再発の一例 (2010)
  • Author(s): 神野歩, 廣田勇士, 隅田健太郎, 有村愛子, 西海智子, 橋本尚子, 井口元三, 坂口一彦, 梶博史, 高橋裕, 清野進, 小川渉
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20100000
• [Presentation] 多発性内分泌腺腫症1型の外来経過観察中に早期診断・治療が可能であった膵グルカゴノーマの一例 (2010)
  • Author(s): 隅田健太郎, 井口元三, 梶博史, 廣田勇士, 神野歩, 有村愛子, 西海智子, 橋本尚子, 塚田俊彦, 坂口一彦, 清野進, 小川渉, 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20100000
• [Presentation] 新規アディポカイン、ケマリンはインスリン分泌および感受性を調節し糖尿病の発症と関わる (2010)
  • Author(s): 高橋路子, 高橋健一, ZolotaryovFyodor, 洪卿秀, 西沢衡, HandayaningsihEvi, 山本雅昭, 古賀大輔, 赤松優, 三宅一彰, 藤本和歌子, 三木隆司, 南幸太郎, 北澤理子, 北澤荘平, 井口元三, 置村康彦, 加治秀介, 春日雅人, 清野進, 千原和夫, 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20100000
• [Presentation] Octreotide LARとPegvisomantの併用療法により初めて寛解に至った浸潤性巨大GH産生腫瘍の一例 (2010)
  • Author(s): 山本雅昭, 隅田健太郎, 井口元三, 村脇あゆみ, 廣田勇士, 橋本尚子, 坂口一彦, 小川渉, 清野進, 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20100000
• [Presentation] IGF-Iは血管平滑筋細胞において細胞老化を促進する (2010)
  • Author(s): HandayaningsihAnastasia Evi, 井口元三, 福岡秀規, 西沢衡, 高橋路子, 山本雅昭, HerningtyasHenny, 置村康彦, 加治秀介, 千原和夫, 清野進, 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 20100000
• [Presentation] 先端巨大症の治療戦略 内科の立場から ランチョンセミナー (2010)
  • Author(s): 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Year and Date: 20100000
• [Presentation] 成人GH分泌不全症の治療適応と効果(成人GH分泌不全症における代謝異常) クリニカルアワー (2009)
  • Author(s): 高橋裕
  • Organizer: 第82回日本内分泌学会総会
  • Place of Presentation: 群馬
  • Year and Date: 20090000
• [Presentation] 成人GH分泌不全症の新たな病態 ランチョンセミナー (2009)
  • Author(s): 高橋裕
  • Organizer: 第82回日本内分泌学会総会
  • Place of Presentation: 群馬
  • Year and Date: 20090000
• [Presentation] 新規アディポカイン、ケマリンの新たな機能:MAF-Aを介して膵β細胞機能を調節し糖尿病発症と関連する シンポジウム (2009)
  • Author(s): 高橋裕
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 内分泌系から見た老化の意義-IGF-Iは成長と老化のリンクである(招待講演) (2009)
  • Author(s): 高橋裕
  • Organizer: GH/IGF-I & Longevity Meeting 2009
  • Place of Presentation: 東京
  • Year and Date: 20090000
• [Presentation] 成人GH分泌不全症の新たな病態 (2009)
  • Author(s): 高橋裕
  • Organizer: 第48回成長ホルモン研究会
  • Place of Presentation: 名古屋
  • Year and Date: 20090000
• [Presentation] 新規アディポカイン、ケマリンは膵β細胞機能を調節し、2型糖尿病患者においてその血中濃度が低下している (2009)
  • Author(s): 高橋路子、西沢衡、Evi Handayaningsih、山本雅昭、古賀大輔、赤松優、猪俣純枝、藤本和歌子、三木隆司、南幸太郎、三宅一彰、北澤理子、北澤荘平、置村康彦、加治秀介、春日雅人、清野進、千原和夫、高橋裕
  • Organizer: 第82回日本内分泌学会総会
  • Place of Presentation: 群馬
  • Year and Date: 20090000
• [Presentation] 下垂体前葉細胞の分化制御の新展開: PIT1に対する自己抗体と関連した後天性GH、PRL、TSH欠損症3例の解析(シンポジウム) (2009)
  • Author(s): 井口元三, 高橋裕, 竹野亮子, 置村康彦, 東條克能, 杢保敦子, 加治秀介, 千原和夫
  • Organizer: 第82回日本内分泌学会総会
  • Place of Presentation: 群馬
  • Year and Date: 20090000
• [Presentation] 新規アディポカイン、ケマリンは膵β細胞機能を調節し、2型糖尿病患者においてその血中濃度が低下している(プレジデントポスター) (2009)
  • Author(s): 高橋路子、西沢衡、Evi Handayaningsih、山本雅昭、古賀大輔、赤松優、猪俣純枝、藤本和歌子、三木隆司、南幸太郎、三宅一彰、北澤理子、北澤荘平、置村康彦、加治秀介、春日雅人、清野進、千原和夫、高橋裕
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 成人GH分泌不全症とNASH(ランチョンセミナー) (2008)
  • Author(s): 高橋裕
  • Organizer: Forum on Growth Hormone Research 2008
  • Place of Presentation: 東京
  • Year and Date: 20080000
• [Presentation] 成人GH分泌不全症の新たな病態と治療の意義(特別講演) (2008)
  • Author(s): 高橋裕
  • Organizer: 成人GH分泌不全症懇話会
  • Place of Presentation: 東京
  • Year and Date: 20080000
• [Presentation] 成人GH分泌不全症の病態と治療の意義、成人におけるGH/IGF-I系の新たな生理作用と治療応用(特別講演) (2008)
  • Author(s): 高橋裕
  • Organizer: 和歌山内分泌学術講演会
  • Place of Presentation: 和歌山
  • Year and Date: 20080000
• [Presentation] 成人GH分泌不全症の病態と治療の意義、成人におけるGH/IGF-I系の新たな生理作用と治療応用(特別講演) (2008)
  • Author(s): 高橋裕
  • Organizer: GH/IGF-I学術講演会
  • Place of Presentation: 東京
  • Year and Date: 20080000
• [Presentation] GH/IGF-I系と寿命(シンポジウム) (2008)
  • Author(s): 高橋裕
  • Organizer: GH/IGF-I & Longevity Meeting
  • Place of Presentation: 東京
  • Year and Date: 20080000
• [Presentation] 先端巨大症の病態と新しい治療法(特別講演、スポンサードセッション) (2008)
  • Author(s): 高橋裕
  • Organizer: 第18回間脳下垂体腫瘍学会
  • Place of Presentation: 福井
  • Year and Date: 20080000
• [Book] 視床下部腫瘍(増刊号) (2011)
  • Author(s): 高橋裕
  • Publisher: 日本臨床(in press)
• [Book] CKDと成長ホルモン (2011)
  • Author(s): 高橋裕
  • Publisher: ホルモンと臨床(in press)
• [Book] 成人GH分泌不全症の成人期管理(58) (2011)
  • Author(s): 高橋裕
  • Total Pages: 41-45
  • Publisher: ホルモンと臨床
• [Book] 成人GH分泌不全症とGH補充療法(内分泌)--(臨床分野での進歩) (2010)
  • Author(s): 高橋裕
  • Total Pages: 233-241
  • Publisher: Annual review,糖尿病・代謝・内分泌
• [Book] 先端巨大症の治療戦略Update(特集IGF-1異常症としての先端巨大症)(45(12)) (2009)
  • Author(s): 高橋裕
  • Total Pages: 95-100
  • Publisher: 医薬ジャーナル
• [Remarks] ホームページ等
  • URL: http://mdl.oops.jp/kobe-diabetes/doctor/activity/acti-04.html