2012 Fiscal Year Final Research Report
Integrated analysis of transcriptional regulation in cancer
| Project/Area Number |
20221009
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Shumpei 東京大学, 医学部, 准教授 (50418638)
TSUTSUMI Shuichi 東京大学, 先端科学技術研究センター, 特任准教授 (30345152)
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| Project Period (FY) |
2008 – 2012
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| Keywords | ゲノム / エピゲノム / がん / 転写制御 / クロマチン |
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| Research Abstract |
With comprehensive genomic and epigenomic analysis, we investigated aberrant regulation of transcription in cancer cells. We identified the target genes directly driven by the transcription factors involved in cellular differentiation and growth, and revealed that epigenomic landscape is dynamically altered during cellular differentiation, oncogene-induced senescence and viral infection. Finally we reported somatic mutations in pancreatic cancer cell lines and hepatocellular carcinoma genome.
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[Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency2012
Author(s)
Wang L, Tsutsumi S, Kawaguchi T,Nagasaki K, Tatsuno K, Yamamoto S, SangF, Sonoda K, Sugawara M, Saiura A,Hirono S, Yamaue H, Miki Y, Isomura M,Totoki Y, Nagae G, Isagawa T, Ueda H,Murayama-Hosokawa S, Shibata T,Sakamoto H, Kanai Y, Kaneda A, Noda T,Aburatani H
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Journal Title
Genome Research
Volume: 22(2)
Pages: 208-19
DOI
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[Journal Article] Global Mapping of Cell-Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation2011
Author(s)
Waki H, Nakamura M, Yamauchi T,Wakabayashi K, Yu J, Hirose-Yotsuya L,Take K, Sun W, Iwabu M, Okada-Iwabu M,Fujita T, Aoyama T, Tsutsumi S, Ueki K,Kodama T, Sakai J, Aburatani H, Kadowaki T
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Journal Title
PLoS Genetics
Volume: 7(10)
Pages: e1002311
DOI
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[Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes2011
Author(s)
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y,Takada K, Aburatani H, Fukayama M
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Journal Title
Cancer Res
Volume: 71(23)
Pages: 7187-97
DOI
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[Journal Article] Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells2011
Author(s)
Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y,Todo T, Yamada Y, Fukayama M, Saito N,Miyazono K, Aburatani H
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Journal Title
Proc Natl Acad Sci USA
Volume: 108(30)
Pages: 12384-9
DOI
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[Journal Article] Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression2011
Author(s)
Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro JI,Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T,Aburatani H, Kodama T, Minami T
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Journal Title
EMBO J
Volume: 30(13)
Pages: 2582-95
DOI
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[Journal Article] High-resolution characterization of a hepatocellular carcinoma genome2011
Author(s)
Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S,Sonoda K, Totsuka H, Shirakihara T,Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kusuda J, Yoshida T, Aburatani H & S h i b a t a T
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Journal Title
Nat Genet
Volume: 43(5)
Pages: 464-9
DOI
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[Journal Article] Tissue-specific demethylation in CpG-poor promoters during cellular differentiation2011
Author(s)
Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A,Yoshiba S, Matsusaka K, Midorikawa Y,Ishikawa S, Soejima H, Fukayama M,Suemori H, Nakatsuji N, Kume S,Aburatani H
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Journal Title
Hum Mol Genetics
Volume: 20(14)
Pages: 2710-21
DOI
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[Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instabilitywith poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway2010
Author(s)
Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K,Ikeda Y, Uehara Y, Fukayama M,McCormick F, Yano T, Taketani Y, Aburatani H
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Journal Title
Oncogene
Volume: 29(13)
Pages: 1897-908
DOI
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[Journal Article] PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt2009
Author(s)
Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y
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Journal Title
Cell
Volume: 136(3)
Pages: 535-50
DOI
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