2013 Fiscal Year Final Research Report
Development and Control of Highly Efficient Catalytic Systems for Cross-and Multicomponent-Coupling Reactions
| Project/Area Number |
20225004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
KAMBE Nobuaki 大阪大学, 工学(系)研究科(研究院), 教授 (60144432)
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| Co-Investigator(Renkei-kenkyūsha) |
KUNIYASU Hitoshi 大阪大学, 大学院工学研究科, 准教授 (00252594)
IWASAKI Takanori 大阪大学, 大学院工学研究科, 助教 (50550125)
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| Project Period (FY) |
2008-05-12 – 2013-03-31
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| Keywords | クロスカップリング / 多成分カップリング / 遷移金属触媒反応 / アート型錯体 / アルキル化 / グルニャール試薬 / ジエン |
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| Research Abstract |
A variety of methods for carbon-carbon bond formation have been developed by the aid of transition metal catalysts, which enabled introduction of congested secondary and tertiary alkyl groups into organic molecules, multi-component coupling incorporating unsaturated hydrocarbons such as alkynes and dienes, and cross coupling via cleavage of unreactive bonds such as C-F, C-O and C-H. These successful results demonstrated potent catalytic reactivities of anionic transition metal species as key intermediates in various synthetic reaction processes. Catalytic reactions for concomitant construct of carbon-carbon bonds and carbon-heteroatom bonds and those using electronically and/or structurally flexible metal complexes were also developed.
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