2011 Fiscal Year Final Research Report
Single-cell on-time molecular analysis by hyper-sensitive video-mass scope
| Project/Area Number |
20229003
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
MASUJIMA Tsutomu 広島大学, 大学院・医歯薬学総合研究科, 教授 (10136054)
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| Co-Investigator(Kenkyū-buntansha) |
TSUYAMA Naohiro 広島大学, 大学院・医歯薬学総合研究科, 講師 (10335747)
MIZUNO Hajime 広島大学, 大学院・医歯薬学総合研究科, 助手 (30457288)
HARADA Takanori 広島大学, 大学院・医歯薬学総合研究科, 研究員 (30350325)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 1細胞質量分析 / ナノスプレー / ダイレクト細胞分析 / ビデオイメージング / 1細胞分子分析ビデオイメージング / メタボロミクス / 細胞内分子動態 |
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| Research Abstract |
We have established“the live single cell mass spectrometry”first in the world by which molecules in a micro-sucked components from interest points of a live single cell can be analyzed exhaustively and directly under microscopic observation within 10 min. Molecular distribution and metabolism in cytoplasm and organelle in a live mast cell, molecular interchanging of differentiating neuron cell, molecular biosynthesis and photo response of live plant cells, drug metabolism of a single hepatic cell, and even molecular contents in only one drop from a single sweat gland have all been analyzed successfully to show the fruitful performance and potential of this new dreaming method.
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