Roles of guidance factors in immune regulation

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20229007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: KIKUTANI Hitoshi Osaka University, 微生物病研究所, 教授 (80161412)
• Project Period (FY): 2008 – 2012
• Keywords: リンパ球 / 免疫制御 / セマフォリン

Research Abstract

セマフォリン分子は神経ネットワークの構築に必須な神経ガイダンス因子ファミリーを形成しているが、多くのセマフォリン分子が免疫細胞上にも発現し、免疫制御においても重要な機能を果たしていることが明らかになりつつある。本研究では、セマフォリン分子による免疫制御の全容解明と免疫病の標的治療への応用を目指して、1)免疫系で発現するセマフォリン分子とその受容体の遺伝子欠損マウスなどを用いた免疫セマフォリンの機能解析、2)免疫細胞に対するセマフォリンの生物活性発揮の分子機構とシグナル伝達の解析、3)阻害抗体やリコンビナント分子用いた分子標的としてのセマフォリン分子の有用性の検証等を行なっている。

Research Products

• [Journal Article] Semaphorins guide cells into the lymphatics by activating myosin II. (2010)
  • Author(s): Takamatsu, H., N.Takegahara, Y.Nakagawa, M.Tomura, M.Taniguchi, R.H.Friedel, H.Rayburn, M.Tessier-Lavigne, Y.Yoshida, T.Okuno, M.Mizui, S.Kang, S.Nojima, T.Tsujimura, Y. Nakatsuji, I.Katayama, T.Toyofuku, H.Kikutani, A.Kumanogoh.
  • Journal Title: Nat Immunol 11 Pages: 594-600
  • Peer Reviewed
• [Journal Article] Immune semaphorins : novel features of neural guidance molecules. (2009)
  • Author(s): Mizui, M., A.Kuanogoh, H. Kikutani
  • Journal Title: J.Clin.Immunol. 29 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells. (2008)
  • Author(s): Toyofuku, T.,J.Yoshida, T.Sugimoto, M.Yamamoto, N.Makino, H.Takamatsu, N.Takegahara, F.Suto, M.Hori, H.Fujisawa, A.Kumanogoh, H.Kikutani
  • Journal Title: Dev.Biol. 321 Pages: 251-262
  • Peer Reviewed
• [Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4. (2008)
  • Author(s): Mizui, M., T.Shikina, H.Arase, K.Suzuki, T.Yasui, P.D.Rennert, A.Kumanogoh, H.Kikutani
  • Journal Title: Int.Immunol. 20 Pages: 695-708
• [Presentation] Comprehensive detection assay of physiological interaction partners for the Epstein-Barr virus latent membrane protein 1 by bimolecular fluorescence complementation system coupled with enhanced retrovirus mutagenesis. (2010)
  • Author(s): Mizui, M., T.Yasui, K.Morita, T.Morimoto, S.Tada, H.Kikutani
  • Organizer: The 14^<th> Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
  • Place of Presentation: Birmingham, UK.
  • Year and Date: 20100904-20100907
• [Presentation] Semaphorins in immune cell communication. (2010)
  • Author(s): Kikutani, H.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan.
  • Year and Date: 20100822-20100827
• [Presentation] A role of protein kinase N1 in quality control of germinal center B cells. (2010)
  • Author(s): Kikutani, H.
  • Organizer: 9^<th> International Conference on Human Leukocyte Differentiation Antigen.
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20100311-20100313
• [Presentation] Semaphorins and inflammatory resonses. (2008)
  • Author(s): Kikutani, H.
  • Organizer: EMBO Workshop "Semaphorin Function & Mechanisms of Action"
  • Place of Presentation: Cernay, France
  • Year and Date: 20080508-20080511