Measurement and control for multiscale-spatiotemporal neurodynamics

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20240023
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sensitivity informatics/Soft computing
• Research Institution: Hokkaido University
• Principal Investigator: GOHARA Kazutosh Hokkaido University, 大学院・工学研究院, 教授 (40153746)
• Project Period (FY): 2008 – 2011
• Keywords: ニューラルネットワーク / 非線形ダイナミクス

Research Abstract

脳の情報処理は、空間的に広がりのあるニューロンのネットワーク中を、電気信号のインパルスが行き交う、時間と空間の極めて広いマルチスケールで生じる時空間ダイナミクスを基盤としている。ばらばらの単体ニューロンが、知覚・運動・記憶・学習を通して、互いに結合しながらネットワークを構築し発達・成長する過程で、個々のニューロンのインパルスがどのようにネットワーク中を伝わっているのかは、脳情報処理の解明・応用を目指す多くの研究者に共通した極めて本質的かつ重要な問題であるにも関わらず、ほとんど解明されていない。
本研究では、この問題に取り組むための研究基盤を構築することを目指し、時間的には約10桁、空間的には約3桁に渡る極めて広いマルチスケールな時空間ニューロダイナミクスの計測と制御を目標とする。具体的には、多電極アレイ上で神経細胞を長期に渡って培養し、インパルスの信号検出およびネットワークの形成過程の観察を行う実験手法を構築し、得られたデータの解析を行う。

Research Products

• [Journal Article] Minimum neuron density for synchronized bursts in a rat cortical culture on multi-electrode arrays (2010)
  • Author(s): D.Ito, H.Tamate, M.Nagayama, T.Uchida, S.Kudoh, K.Gohara
  • Journal Title: Neuroscience 171(1) Pages: 50-61
  • Peer Reviewed
• [Journal Article] T.Uchida, K.Gohara: Shrinking and Development of Lipid Droplets in Adipocytes during Catecholamine-induced Lipolysis (2010)
  • Author(s): M.Nagayama, K.Shimizu, T.Taira
  • Journal Title: FEBS Lett 584(1) Pages: 86-92
  • Peer Reviewed
• [Journal Article] Estimation of functional connectivity that causes burst-like population activities (2009)
  • Author(s): M.Nomura, D.Ito, H.Tamate, K.Gohara , T.Aoyagi
  • Journal Title: FORMA 24 Pages: 11-16
  • Peer Reviewed
• [Journal Article] Automata on Fractal Sets Observed in Hybrid Dynamical Systems (2008)
  • Author(s): J.Nishikawa K.Gohara
  • Journal Title: International Journal of Bifurcation and Chaos Vol.18, No.12, Pages: 3665-3678
  • Peer Reviewed
• [Journal Article] Anomaly of fractal dimensions observed in stochastically switched systems (2008)
  • Author(s): J.Nishikawa , K.Gohara
  • Journal Title: Physical Review E 77 Pages: 036210.1-8
  • Peer Reviewed
• [Presentation] Long-term measurement of excitatory and inhibitory synapse densities with electrical activity during development of cultured rat cortical networks (2010)
  • Author(s): D.Ito, H.Tamate, T.Komatu, K.Gohara
  • Organizer: Proc.MEA Meeting 2010
  • Place of Presentation: Reutlingen, Germany
  • Year and Date: 2010-07-30
• [Presentation] Cell patterning based on the micro-structured organosilane layer fabricated by VUV lithography (2009)
  • Author(s): M.Yamaguchil, K.Ikedal, M.Suzuki, S.N.Kudohl, A.Kiyohara,T.Uchida, K.Gohara, K.Shimizu, T.Taira
  • Organizer: 1st Int.Conf. on Multifunctional, Hybrid and Nanomaterials
  • Place of Presentation: Tours, Francec (the Vinci Convention Center)
  • Year and Date: 2009-03-16
• [Presentation] Immunocytochemstry in low-density culture of neurons on multielectrode arrayes is effective for identification of action-potential pathway (2008)
  • Author(s): D.Ito, H.Tamate, M.Nomura, T.Aoyagi, K.Gohara
  • Organizer: Proceedings of neuroscience 2008.
  • Place of Presentation: Washington Conference Center, Washington D.C., USA.
  • Year and Date: 2008-11-19
• [Presentation] Estimation of functional connectivity on cultured neuronal networks, Dynamics Days Asia Pacific 5 (2008)
  • Author(s): M.Nomura, D.Ito, H. Tamate, K.Gohara, T.Aoyagi
  • Organizer: The 5th International Conference on Nonlinear Science
  • Place of Presentation: Nara Prefectual New Public Hall, Nara, Japan
  • Year and Date: 2008-09-11
• [Presentation] Immunostainig for Identification of Neuronal-Impulse Pathway on Multielectrode Araays (2008)
  • Author(s): D.Ito, H.Tamate, M.Nagayama, T.Uchida, K.Gohara
  • Organizer: Proc.MEA Meeting 2008, Reutlingen, Germany, 2008
  • Place of Presentation: Friedrich-List-Halle,Reutlingen, Germany
  • Year and Date: 2008-07-10