2011 Fiscal Year Final Research Report
Measurement and control for multiscale-spatiotemporal neurodynamics
| Project/Area Number |
20240023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sensitivity informatics/Soft computing
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Tutomu 北海道大学, 大学院・工学研究院, 准教授 (70356575)
NAGAYAMA Masafumi 北海道大学, 大学院・工学研究院, 助教 (70374585)
SHIOYA Hiroyuki 室蘭工業大学, 工学部, 教授 (90271642)
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| Project Period (FY) |
2008 – 2011
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| Keywords | ニューラルネットワーク / ダイナミクス / 培養神経細胞 / マルチスケール |
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| Research Abstract |
This project has challenged to measurement and control of multi-scale spatiotemporal neuronal dynamics, three-figure spatially and ten-figure temporally. The aim of the project is as follows ; long term culture on multi-electrode array, detection of impulses, observation of way of growing neuronal networks, and analysis of obtained data. As a result, we established long term primary neuronal dissociative cell culture on multi-electrode arrays. Moreover, immunocytochemistry of some proteins was also established for main parts of neuron during several month. The main subject of construction of experimental systems to attack basic problems in neuroscience was achieved. Using constructed system, we obtained important issues of the related field. One of the results is a minimum density of surviving neurons that caused synchronized bursts. Further development of the present works is expected to execute the future fruitful studies on spatiotemporal neuronal dynamics.
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[Journal Article] Contrary Effects of Octopamine Receptor Ligands on Behavioral and Neuronal Changes in Locomotion of Lymnaea2010
Author(s)
Y. Miyamae, M. Komuro, A. Murata, K. Aono, K. Nishikata, A. Kanazawa, Y. Fujito, T. Komatsu, D. Ito, T. Abe, M. Nagayama, T. Uchida, K. Gohara, J. Murakami, R. Kawai, D. Hatakeyama, K. Lukowiak, and E. Ito
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Journal Title
Biol. Bull
Volume: 218
Pages: 6-14
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