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2010 Fiscal Year Self-evaluation Report

Mechanisms to form neural circuits of the spinal cord and cerebellum

Research Project

  • PDF
Project/Area Number 20240029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionChiba University

Principal Investigator

SAITO Tetsuichiro  Chiba University, 大学院・医学研究院, 教授 (00202078)

Project Period (FY) 2008 – 2011
Keywords分子 / 細胞神経科学
Research Abstract

脊髄と小脳の共通点を軸に、神経回路網の構築機構を互いに比較しながら解析することにより、神経細胞の誕生から神経回路網の形成までを制御する普遍的プログラムを解明することを目的とする。特に、申請者等が明らかにしてきたMbh1 や電気穿孔法などを駆使することにより、細胞系譜や分化因子の視点で脊髄神経回路網の構築機構を明らかにするとともに、小脳の初期発生機構を分子レベルで明らかにし、両研究の成果を統合することにより、神経回路網の設計図を解明することを目指す。

  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes2010

    • Author(s)
      Daisuke Kawauchi, Yoko Muroyama Tatsuya Sato, Tetsuichiro Saito
    • Journal Title

      Dev.Biol. 344

      Pages: 1026-1034

    • Peer Reviewed
  • [Journal Article] Embryonic in vivo electroporation in the mouse. in "Guide to Techniques in Mouse Development, Part B"2010

    • Author(s)
      Tetsuichiro Saito
    • Journal Title

      Methods in Enzymology(edited by Paul M.Wasserman and Philip M.Soriano.Academic Press.) 477

      Pages: 37-50

  • [Journal Article] Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch2009

    • Author(s)
      Yuko Muroyama, Tetsuichiro Saito
    • Journal Title

      Development 136

      Pages: 3889-3893

    • Peer Reviewed
  • [Journal Article] Transcriptional cascade from Math1 to Mbhl and Mbh2 is required for cerebellar granule cell differentiation2008

    • Author(s)
      Daisuke Kawauchi, Tetsuichiro Saito
    • Journal Title

      Dev.Biol. 322

      Pages: 345-354

    • Peer Reviewed
  • [Journal Article] Consequence of the loss of Sox2 in the developing brain of the mouse.2008

    • Author(s)
      Satoru Miyagi, Shinji Masui, Hitoshi Niwa, Tetsuichiro Saito, Takuya Shimazaki, Hideyuki Okano, Masazumi Nishimoto, Masami Muramatsu, Atsushi Iwama, Akihiko Okuda
    • Journal Title

      FEBS Lett 582

      Pages: 2811-2815

    • Peer Reviewed
  • [Presentation] Major guidance receptor genes are differentially regulated downstream of Barh genes2010

    • Author(s)
      Tetsuichiro Saito
    • Organizer
      in commissural neurons
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-11-03
  • [Presentation] 神経回路の構築を制御する遺伝子カスケード2010

    • Author(s)
      斎藤哲一郎
    • Organizer
      第1回発生システムシンポジウム「細胞と個体をつなぐメカニズム」
    • Place of Presentation
      千葉
    • Year and Date
      2010-02-15
  • [Presentation] 神経ネットワークを構築する機構2010

    • Author(s)
      斎藤哲一郎
    • Organizer
      第3回ちばBasic & Clinical Research Conference
    • Place of Presentation
      千葉
    • Year and Date
      2010-02-06
  • [Presentation] 大脳皮質神経前駆細胞の維持におけるNotch下流因子Neproの機能2009

    • Author(s)
      室山優子, 斎藤哲一郎
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
  • [Presentation] マウス脊髄における部域特異的な細胞分化制御2009

    • Author(s)
      室山優子
    • Organizer
      第5回Chiba Neuroresearch Meeting
    • Place of Presentation
      千葉
    • Year and Date
      2009-05-30
  • [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制2008

    • Author(s)
      川内大輔, 斎藤哲一郎
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
  • [Book] Notch signaling in embryology and cancer(Nepro : A novel Notch effector for maintenanance of neural progenitor cells in the neocortex)(edited by jorg Reichrath and Sandra Reichrath)2010

    • Author(s)
      Tetsuichiro Saito
    • Total Pages
      1-10
    • Publisher
      Landes Bioscience.
  • [Book] Encyclopedia of Neuroscience(Transcriptional factor)(edited by Marc D.Binder, Nobutaka Hirokawa and Uwe Windhorst)2009

    • Author(s)
      Tetsuichiro Saito
    • Total Pages
      4096-4099
    • Publisher
      Springer
  • [Remarks] ホームページ

    • URL

      http://www.m.chiba-u.ac.jp/class/dev/index.html

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Published: 2012-02-13   Modified: 2016-04-21  

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