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2011 Fiscal Year Final Research Report

Mechanisms to form neural circuits of the spinal cord and cerebellum

Research Project

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Project/Area Number 20240029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionChiba University

Principal Investigator

SAITO Tetsuichiro  千葉大学, 大学院・医学研究院, 教授 (00202078)

Co-Investigator(Kenkyū-buntansha) MUROYAMA Yuko  千葉大学, 大学院・医学研究院, 特任講師 (20422248)
KAWAUCHI Daisuke  千葉大学, 大学院・医学研究院, 助教 (10400996)
Project Period (FY) 2008 – 2011
Keywords分子 / 細胞神経科学
Research Abstract

The spinal cord and cerebellum are morphologically and functionally different. Our previous results, however, have suggested that commissural neurons in the spinal cord and granule cells in the cerebellum are generated by the same genes. This research project has revealed novel relationship between the genes in neuronal differentiation and neural circuit formation in the spinal cord and cerebellum.

  • Research Products

    (16 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Nepro : A novel Notch effector for the maintenance of neural progenitor cells in the neocortex2011

    • Author(s)
      Tetsuichiro Saito
    • Journal Title

      Adv. Exp. Med. Biol

      Volume: 727 Pages: 61-70

    • DOI

      DOI:10.1007/978-1-4614-0899-4_5

  • [Journal Article] Expression of major guidance receptors is differentially regulated in spin al commissural neurons transfated by mammalian Barh genes2010

    • Author(s)
      Daisuke Kawauchi, Yuko Muroyama, Tatsuya Sato and Tetsuichiro Saito
    • Journal Title

      Dev. Biol

      Volume: 344 Pages: 1026-1034

    • DOI

      DOI:10.1016/j.ydbio.2010.06.025

    • Peer Reviewed
  • [Journal Article] Embryonic in vivo electroporation in the mouse. in "Guide to Techniques in Mouse Development, Part B" edited by Paul M2010

    • Author(s)
      Tetsuichiro Saito
    • Journal Title

      Wasserman and Philip M. Soriano. Methods in Enzymology

      Volume: 477 Pages: 37-50

    • DOI

      DOI:10.1016/S0076-6879(10)77003-8

  • [Journal Article] Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch2009

    • Author(s)
      Yuko Muroyama Tetsuichiro Saito
    • Journal Title

      Development

      Volume: 136 Pages: 3889-3893

    • DOI

      DOI:10.1242/dev.039180

    • Peer Reviewed
  • [Journal Article] Transcriptional cascade fromMath1 toMbh1and Mbh2is required for cerebellar granule cell differentiation2008

    • Author(s)
      Daisuke Kawauchi Tetsuichiro Saito
    • Journal Title

      Dev. Biol

      Volume: 322 Pages: 345-354

    • DOI

      DOI:10.1016/j.ydbio.2008.08.005

    • Peer Reviewed
  • [Journal Article] Consequence of the loss of Sox2 in the developing brain of the mouse2008

    • Author(s)
      Satoru Miyagi, Shinji Masui, Hitoshi Niwa, Tetsuichiro Saito, Takuya Shimazaki, Hideyuki Okano, Masazumi Nishimoto, Masami Muramatsu, Atsushi Iwama Akihiko Okuda
    • Journal Title

      FEBS Lett

      Volume: 582 Pages: 2811-2815

    • DOI

      DOI:10.1016/j.febslet.2008.07.011

    • Peer Reviewed
  • [Presentation] Nepro is required for the maintenance of neural progenitor cells in the early neocortex2012

    • Author(s)
      Tetsuichiro Saito
    • Organizer
      1st International Symposium Neocortex Organization
    • Place of Presentation
      岡崎
    • Year and Date
      2012-03-12
  • [Presentation] 大脳皮質神経前駆細胞の維持に必要な遺伝子Neproの機能解析2011

    • Author(s)
      佐藤達也, 室山優子, 斎藤哲一郎
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
  • [Presentation] Major guidance receptor genes are differentially regulated downstream of Barh genes in commissural neurons2010

    • Author(s)
      Tetsuichiro Saito
    • Organizer
      Society for neuroscience 40th annual meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-11-03
  • [Presentation] 神経回路の構築を制御する遺伝子カスケード2010

    • Author(s)
      斎藤哲一郎
    • Organizer
      第1回発生システムシンポジウム「細胞と個体をつなぐメカニズム」
    • Place of Presentation
      千葉
    • Year and Date
      2010-02-15
  • [Presentation] 神経ネットワークを構築する機構2010

    • Author(s)
      斎藤哲一郎
    • Organizer
      第3回ちばBasic & Clinical Research Conference
    • Place of Presentation
      千葉
    • Year and Date
      2010-02-06
  • [Presentation] 大脳皮質神経前駆細胞の維持におけるNotch下流因子Neproの機能2009

    • Author(s)
      室山優子, 斎藤哲一郎
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
  • [Presentation] マウス脊髄における部域特異的な細胞分化制御2009

    • Author(s)
      室山優子
    • Organizer
      第5回Chiba Neuroresearch Meeting
    • Place of Presentation
      千葉
    • Year and Date
      2009-05-30
  • [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制2008

    • Author(s)
      川内大輔, 斎藤哲一郎
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
  • [Book] Encyclopedia of Neuroscience edited by Marc D. Binder, Nobutaka Hirokawa and Uwe Windhorst2009

    • Author(s)
      Tetsuichiro Saito
    • Total Pages
      4096-4099
    • Publisher
      Transcriptional factor
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/d ev/index.html

URL: 

Published: 2013-07-31  

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