functional studies of genes selectively expressed in primate neocortical areas

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20240030
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Basic Biology
• Principal Investigator: YAMAMORI Tetsuo National Institute for Basic Biology, 脳生物学研究部門, 教授 (80260206)
• Project Period (FY): 2008 – 2012
• Keywords: 大脳皮質 / 領野 / 視覚野 / 連合野 / 霊長類 / ウイルスベクター / 遺伝子発現

Research Abstract

我々は、霊長類の大脳皮質領野特異的に発現する遺伝子の解析により、霊長類の大脳皮質の特質を解明したいと考えて研究を行っている。これら霊長類の領野特異的発現遺伝子は、大別すると視覚野特異的に発現するもの(occ1,testican-1/2,5HT1B/2A)と連合野特異的に発現するもの(Rbp,SPARC,PNMA5,SLIT1)の2群に分けられる。本研究では、ウイルスベクター等を用いた遺伝子導入法によりこれらの遺伝子のgain of functionやloss of function法により、これらの遺伝子の生理的な機能を明らかにすることを目的として研究を行っている。

Research Products

• [Journal Article] Differential expression patterns of OCC1-related, extracellular matrix proteins in the lateral geniculate nucleus of macaque monkeys. (2010)
  • Author(s): Takahata, T., Hashikawa, T., Tochitani, S., Yamamori, T.
  • Journal Title: J.Chem.Neuroanat. 40 Pages: 112-122
  • Peer Reviewed
• [Journal Article] Prefrontal-enriched SLIT1 expression in Old World monkey cortex established during the postnatal development. (2010)
  • Author(s): Sasaki, T., Komatsu, Y., Watakabe, A., Sawada, K., Yamamori, T.
  • Journal Title: Cereb.Cortex 20 Pages: 2496-2510
  • Peer Reviewed
• [Journal Article] Fluorescent in situhybridization technique for cell type identification and characterization in the central nervous system. (2010)
  • Author(s): Watakabe, A., Komatsu, Y., Ohsawa, S., Yamamori, T.
  • Journal Title: Methods.(Review)(招待) 52 Pages: 367-374
  • Peer Reviewed
• [Journal Article] Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation. (2009)
  • Author(s): Takahata T, Higo N, *Kaas JH, Yamamori T.
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 12151-12155
  • Peer Reviewed
• [Journal Article] Paraneoplastic Antigen-Like 5 Gene (PNMA5) Is Preferentially Expressed in the Association Areas in a Primate Specific Manner. (2009)
  • Author(s): Takaji M, Komatsu Y, Watakabe A, Hashikawa T, *Yamamori T.
  • Journal Title: Cereb Cortex. 19 Pages: 2865-2879
  • Peer Reviewed
• [Presentation] Neuronal oscillation and sensory-motor integration in superior colliculus. (2010)
  • Author(s): Hirokawa, J., Sadakane, O., Sakata, S., Sakurai, Y., Yamamori, T
  • Organizer: 40th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 20101113-20101117
• [Presentation] Tet-off lentiviral vectors drive high-level transgene expression in marmoset brains. (2010)
  • Author(s): Watakabe, A., Takaji, M., Nakagami, Y., Hioki, H., Kaneko, T., Kato, S., Kobayashi, K., Kawashima, T., Okuno, H., Bitom H., Kitamura, Y., Yamamori, T.
  • Organizer: 40th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 20101113-20101117
• [Presentation] 霊長類前頭前皮質に強いSLIT1の発現パターンは生後発生で確立する (2010)
  • Author(s): 佐々木哲也、小松勇介、渡我部昭哉、澤田薫、山森哲雄
  • Organizer: 第33回日本神経科学会大会(演題番号:P2-d12)
  • Place of Presentation: 神戸
  • Year and Date: 20100902-20100904
• [Presentation] TET-OFFレンチウイルスベクターによるマーモセット脳への遺伝子導入 (2010)
  • Author(s): 渡我部昭哉、高司雅史、仲神友貴、日置寛之、金子武嗣、加藤成樹、小林和人、川島尚之、奥野浩行、尾藤晴彦、北村義浩、山森哲雄
  • Organizer: 第33回日本神経科学会大会(演題番号:P1-r28)
  • Year and Date: 2010-09-02
• [Remarks] ホームページ
  • URL: http://www.nibb.ac.jp/~divspel/