2012 Fiscal Year Final Research Report
functional studies of genes selectively expressed in primate eocortical areas
| Project/Area Number |
20240030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
YAMAMORI Tetsuo 基礎生物学研究所, 脳生物学研究部門, 教授 (80260206)
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| Co-Investigator(Kenkyū-buntansha) |
ONOE Hirotaka 独立行政法人理化学研究所, 分子イメージング科学研究センター, チームリーダー (80214196)
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| Co-Investigator(Renkei-kenkyūsha) |
WATAKABE Akiya 基礎生物学研究所, 脳生物学研究部門, 准教授 (40290910)
KOMINE Yuriko 基礎生物学研究所, 脳生物学研究部門, 助教 (90280586)
SADAKANE Osamu 基礎生物学研究所, 脳生物学研究部門, 助教 (90446261)
KOMATSU Yusuke 生理学研究所, 多次元共同脳科学推進センター・脳科学新領域開拓研究室, 特任助教 (80450203)
HIROKAWA Junya 基礎生物学研究所, 脳生物学研究部門, 特別協力研究員 (40546470)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 大脳皮質 / 領野 / 視覚野 / 連合野 / 霊長類 / ウイルスベクター / 遺伝子発現 |
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| Research Abstract |
First, we aimed to analyze the function of the genes selectively expressed in the primate neocortical areas in comparison with that in rodents. We examined the expression of c-Fos when rats were subjected to an audio-visual multisensory task. We found that specific enhancement of c-Fos expression in V2L (the lateral secondary visual area) upon being exposed to the task. Using previously developed cortical box method, we analyzed three layer specific genes (RORb, ER81, Nurr1) in the rat neocortex. Each of three genes showed a mutually exclusive and complimentary expression pattern, which demonstrated that the areas in rodents were able to be automatically or objectively described although the area selective expression was not as prominent as that in primates. We reported SLIT1 as a gene that was selectively expressed in the association areas of the macaque neocortex. Finally, we have established the gene manipulation system in the primate neocortex
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[Journal Article] Visualization of Cortical Projection Neurons with Retrograde TET-Off Lentiviral Vector2012
Author(s)
Akiya Watakabe, Shigeki Kato, Kazuto Kobayashi, Masafumi Takaji, Yuki Nakagami, Osamu Sadakane, Masanari Ohtsuka, Hiroyuki Hioki, Takeshi Kaneko, Hiroyuki Okuno, Takashi Kawashima, Haruhiko Bito, Yoshihiro Kitamura Tetsuo Yamamori.
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Journal Title
PLoS One
Volume: 7
Pages: (10)
DOI
Peer Reviewed
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[Journal Article] Genetic dissection of the circuit for hand dexterity in primates2012
Author(s)
Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi & Tadashi Isa
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Journal Title
Nature
Volume: 487
Pages: 235-238
DOI
Peer Reviewed
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[Journal Article] Roberto Sprea fico, and Rita Garbelli2011
Author(s)
Laura Rossini, Ramona F. Moroni, Laura Tassi, Akiya Watakabe, Tetsuo Yamamori
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Journal Title
Altered layer-specific gene expression in cortical samples from patients with temporal lobe epilepsy
Volume: 52(10)
Pages: 1928-1937
DOI
Peer Reviewed
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[Journal Article] A novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in mice2011
Author(s)
Takashi Kitsukawa, Masatoshi Nagata, Dai Yanagihara, Ryohei Tomioka, Hideko Utsumi, Yasuo Kubota, Takeshi Yagi, Ann M.Graybiel, and Tetsuo Yamamori
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Journal Title
Journal of Neurophysiology
Volume: 106(1)
Pages: 479-487
DOI
Peer Reviewed
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