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2012 Fiscal Year Final Research Report

functional studies of genes selectively expressed in primate eocortical areas

Research Project

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Project/Area Number 20240030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Institute for Basic Biology

Principal Investigator

YAMAMORI Tetsuo  基礎生物学研究所, 脳生物学研究部門, 教授 (80260206)

Co-Investigator(Kenkyū-buntansha) ONOE Hirotaka  独立行政法人理化学研究所, 分子イメージング科学研究センター, チームリーダー (80214196)
Co-Investigator(Renkei-kenkyūsha) WATAKABE Akiya  基礎生物学研究所, 脳生物学研究部門, 准教授 (40290910)
KOMINE Yuriko  基礎生物学研究所, 脳生物学研究部門, 助教 (90280586)
SADAKANE Osamu  基礎生物学研究所, 脳生物学研究部門, 助教 (90446261)
KOMATSU Yusuke  生理学研究所, 多次元共同脳科学推進センター・脳科学新領域開拓研究室, 特任助教 (80450203)
HIROKAWA Junya  基礎生物学研究所, 脳生物学研究部門, 特別協力研究員 (40546470)
Project Period (FY) 2008 – 2012
Keywords大脳皮質 / 領野 / 視覚野 / 連合野 / 霊長類 / ウイルスベクター / 遺伝子発現
Research Abstract

First, we aimed to analyze the function of the genes selectively expressed in the primate neocortical areas in comparison with that in rodents. We examined the expression of c-Fos when rats were subjected to an audio-visual multisensory task. We found that specific enhancement of c-Fos expression in V2L (the lateral secondary visual area) upon being exposed to the task. Using previously developed cortical box method, we analyzed three layer specific genes (RORb, ER81, Nurr1) in the rat neocortex. Each of three genes showed a mutually exclusive and complimentary expression pattern, which demonstrated that the areas in rodents were able to be automatically or objectively described although the area selective expression was not as prominent as that in primates. We reported SLIT1 as a gene that was selectively expressed in the association areas of the macaque neocortex. Finally, we have established the gene manipulation system in the primate neocortex

  • Research Products

    (27 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 16 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Monocular inhibition reveals temporal and spatial changes in gene expression in the primary visual cortex of marmoset2013

    • Author(s)
      Yuki Nakagami, Akiya Watakabe and Tetsuo Yamamori
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 7 Pages: (43)

    • DOI

      doi:10.3389/fncir.2013.00043

    • Peer Reviewed
  • [Journal Article] Diversity of Retinal Ganglion Cells Identified by Transient GFP Transfection in Organotypic Tissue Culture of Adult Marmoset Monkey Retina2013

    • Author(s)
      Satoru Moritoh, Yusuke Komatsu, Tetsuo Yamamori, Amane Koizumi
    • Journal Title

      PLoS One

      Volume: 8 Pages: (1)

    • DOI

      doi:10.1371/journal.pone.0054667

    • Peer Reviewed
  • [Journal Article] Behavioral abnormalities observed in Zfhx2-deficient mice2012

    • Author(s)
      Yuriko Komine, Keizo Takao, Tsuyoshi Miyakawa, Tetsuo Yamamori
    • Journal Title

      PLoS One

      Volume: 7 Pages: (12)

    • DOI

      doi:10.1371/journal.pone.0053114

    • Peer Reviewed
  • [Journal Article] 霊長類の大脳皮質視覚野と連合野で顕著に発現する遺伝子の機能的意義2012

    • Author(s)
      山森哲雄
    • Journal Title

      生体の科学

      Volume: Vol.63 No.6 Pages: 592-598

  • [Journal Article] Visualization of Cortical Projection Neurons with Retrograde TET-Off Lentiviral Vector2012

    • Author(s)
      Akiya Watakabe, Shigeki Kato, Kazuto Kobayashi, Masafumi Takaji, Yuki Nakagami, Osamu Sadakane, Masanari Ohtsuka, Hiroyuki Hioki, Takeshi Kaneko, Hiroyuki Okuno, Takashi Kawashima, Haruhiko Bito, Yoshihiro Kitamura Tetsuo Yamamori.
    • Journal Title

      PLoS One

      Volume: 7 Pages: (10)

    • DOI

      doi:10.1371/journal.pone.0046157

    • Peer Reviewed
  • [Journal Article] Genetic dissection of the circuit for hand dexterity in primates2012

    • Author(s)
      Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi & Tadashi Isa
    • Journal Title

      Nature

      Volume: 487 Pages: 235-238

    • DOI

      doi:10.1038/nature11206

    • Peer Reviewed
  • [Journal Article] Area-Specific Substratification of Deep Layer Neurons in the Rat Cortex2012

    • Author(s)
      Akiya Watakabe, Junya Hirokawa, Noritaka Ichinohe, Sonoko Ohsawa, Takeshi Kaneko, Kathleen S. Rockland, and Tetsuo Yamamori
    • Journal Title

      The Journal of Comparative Neurology

      Volume: 520(16) Pages: 3553-3573

    • DOI

      doi:10.1002/cne.23160

    • Peer Reviewed
  • [Journal Article] Differential expression patterns of striate cortex-enriched genes among Old World, New World, and prosimian primates2012

    • Author(s)
      Toru Takahata, Rammohan Shukla, Tetsuo Yamamori and Jon H. Kaas
    • Journal Title

      Cerebral Cortex

      Volume: 22(10) Pages: 2313-2321

    • DOI

      doi:10.1093/cercor/bhr308

    • Peer Reviewed
  • [Journal Article] Multisensory information facilitates reaction speed by enlarging activity difference between superior colliculus hemispheres in rats2011

    • Author(s)
      Junya Hirokawa, Osamu Sadakane, Shuzo Sakata, Miquel Bosch, Yoshio Sakurai, Tetsuo Yamamori
    • Journal Title

      PLoS ONE

      Volume: 6(9) Pages: e25283

    • DOI

      doi:10.1371/journal.pone.0025283

    • Peer Reviewed
  • [Journal Article] Roberto Sprea fico, and Rita Garbelli2011

    • Author(s)
      Laura Rossini, Ramona F. Moroni, Laura Tassi, Akiya Watakabe, Tetsuo Yamamori
    • Journal Title

      Altered layer-specific gene expression in cortical samples from patients with temporal lobe epilepsy

      Volume: 52(10) Pages: 1928-1937

    • DOI

      doi:10.1111/j.1528-1167.2011.03246.x

    • Peer Reviewed
  • [Journal Article] Selective gene expression in regions of primate neocortex: Implications for cortical specialization2011

    • Author(s)
      Tetsuo Yamamori
    • Journal Title

      Progress in Neurobiology

      Volume: 94(3) Pages: 201-222

    • DOI

      doi:10.1016/j.pneurobio.2011.04.008

    • Peer Reviewed
  • [Journal Article] A novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in mice2011

    • Author(s)
      Takashi Kitsukawa, Masatoshi Nagata, Dai Yanagihara, Ryohei Tomioka, Hideko Utsumi, Yasuo Kubota, Takeshi Yagi, Ann M.Graybiel, and Tetsuo Yamamori
    • Journal Title

      Journal of Neurophysiology

      Volume: 106(1) Pages: 479-487

    • DOI

      487, 2011,

    • Peer Reviewed
  • [Journal Article] 脳の蛍光in situ hybridization法2011

    • Author(s)
      渡我部昭哉、小松勇介、山森哲雄
    • Journal Title

      実験医学

      Volume: Vol.29、No.3 Pages: 467-472

  • [Journal Article] Fluorescent in situ hybridization technique for cell type identification and characterization in the central nervous system2010

    • Author(s)
      Akiya Watakabe, Yusuke Komatsu , Sonoko Ohsawa, Tetsuo Yamamori
    • Journal Title

      Methods

      Volume: 52(4) Pages: 367-374

    • DOI

      doi:10.1016/ j.ymeth.2010.07.003

    • Peer Reviewed
  • [Journal Article] Differential expression patterns of OCC1-related, extracellular matrix proteins in the lateral geniculate nucleus of macaque monkeys2010

    • Author(s)
      Toru Takahata, Tsutomu Hashikawa, Shiro Tochitani, Tetsuo Yamamori
    • Journal Title

      Journal of Chemical Neuroanatomy

      Volume: 40(2) Pages: 112-122

    • DOI

      doi:10.1016/j.jchemneu.2010.05.001

    • Peer Reviewed
  • [Journal Article] Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT1A and 5-HT2A Receptors2010

    • Author(s)
      M. Victoria Puig, Akiya Watakabe, Mika Ushimaru, Tetsuo Yamamori, and Yasuo Kawaguchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 30(6) Pages: 2211-2222

    • DOI

      doi:10.1523/JNEUROSCI.3335-09.2010

    • Peer Reviewed
  • [Journal Article] Prefrontal-enriched SLIT1 expression in Old World monkey cortex established during the postnatal development2010

    • Author(s)
      Tetsuya Sasaki, Yusuke Komatsu, Akiya Watakabe, Kaoru Sawada and Tetsuo Yamamori
    • Journal Title

      Cereb Cortex

      Volume: 20(10) Pages: 2496-2510

    • DOI

      doi:10.1093/cercor/bhp319

    • Peer Reviewed
  • [Journal Article] Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation2009

    • Author(s)
      Toru Takahata, Noriyuki Higo, Jon H. Kaas, and Tetsuo Yamamori
    • Journal Title

      PNAS

      Volume: 106(29) Pages: 12151-12155

  • [Journal Article] Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner2009

    • Author(s)
      Masafumi Takaji, Yusuke Komatsu, Akiya Watakabe, Tsutomu Hashikawa and Tetsuo Yamamori
    • Journal Title

      Cerebral Cortex

      Volume: 19(12) Pages: 2865-2879

    • DOI

      doi:10.1093/cercor/bhp062

    • Peer Reviewed
  • [Presentation] Light induction causes dynamic alteration in the expression of activity-dependent genes in the marmoset primary visual cortex2012

    • Author(s)
      Yuki Nakagami
    • Organizer
      Society for Neuroscience 2012, Tuesday
    • Place of Presentation
      Ernest N. Morial Convention Center, USA
    • Year and Date
      2012-10-16
  • [Presentation] Visualization of the cortical projection neuron subtypes by TET-double infection method (TEDI)2012

    • Author(s)
      Akiya Watakabe
    • Organizer
      Society for Neuroscience 2012, Saturday
    • Place of Presentation
      Ernest N. Morial Convention Center, USA
    • Year and Date
      2012-10-13
  • [Presentation] Lentivirus-mediated gene delivery of cortical area-specific promoter-eGFP tothe marmoset monkey cortical slice culture2011

    • Author(s)
      Katsusuke Hata
    • Organizer
      Society for Neuroscience 2011, Tuesday
    • Place of Presentation
      Walter E. Washington Convention Center, USA
    • Year and Date
      2011-11-15
  • [Presentation] Comparison of layer 4 neurons in the primary visual cortex and the barrel cortex2011

    • Author(s)
      Osamu Sadakane
    • Organizer
      Society for Neuroscience 2011, Sunday
    • Place of Presentation
      Walter E. Washington Convention Center, USA
    • Year and Date
      2011-11-13
  • [Presentation] Evolutionary changes in V1-selective gene expression in primate species2011

    • Author(s)
      Toru Takahata
    • Organizer
      Society for Neuroscience 2011, Sunday
    • Place of Presentation
      Walter E. Washington Convention Center, USA
    • Year and Date
      2011-11-13
  • [Presentation] Tet-off lentiviral vectors drive high-level transgene expression in marmoset brains2010

    • Author(s)
      Akiya Watakabe
    • Organizer
      Society for Neuroscience 2010, Tuesday, November 16, 2010
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      20100000
  • [Presentation] Neuronal oscillation and sensory-motor integration in superior colliculus2010

    • Author(s)
      Junya Hirokawa
    • Organizer
      Society for Neuroscience 2010, Wednesday
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      2010-11-17
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/divspe1/

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Published: 2014-08-29   Modified: 2015-05-13  

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