2012 Fiscal Year Final Research Report
Molecular mechanisms of structural plasticity of dendritic spine
Project/Area Number |
20240032
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
HAYASHI Yasunori 独立行政法人理化学研究所, 記憶メカニズム研究チーム, チームリーダー (90466037)
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Project Period (FY) |
2008 – 2012
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Keywords | 細胞・組織 / シグナル伝達 / 神経科学 / 生理学 / 脳・神経 / 記憶学習 / シナプス可塑性 |
Research Abstract |
We found autophosphorylation of CaMKII on multiple serine and threonine residues on F-actin binding domain detaches CaMKII from F-actin. We concluded that CaMKII bundles F-actin under basal neuronal activity but when it is activated, it releases F-actin, thereby allowing its modification. This results in structural plasticity. In this way, we speculate that CaMKII act as a gate of structural plasticity.
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[Journal Article] A rapid and effective FISH protocol with hybridization-sensitive fluorescent linear oligo probes2012
Author(s)
Wang, D.O., Matsuno, H., Ikeda, S., Nakamura, A., Yanagisawa, H., Hayashi, Y., Okamoto, A
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Journal Title
RNA
Volume: 18
Pages: 166-175
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[Journal Article] Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo2011
Author(s)
Mower, A. F., Kwok, S. M., Yu, H., Majewska, A. K., Okamoto, K.-I., Hayashi, Y.*, Sur, M.* (*: co-corresponding authors)
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Journal Title
Proc. Natl. Acad. Sci
Volume: 108
Pages: 21241-21246
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[Journal Article] The postsynaptic density proteins Homer and Shank form a polymeric network structure2009
Author(s)
Hayashi, M.K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M.H., Xu, R.-M., Li, H., Sala, C., Hayashi, Y
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Journal Title
Cell
Volume: 137
Pages: 159-171
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[Presentation] The role of CaMKII beta in modulating dendritic spine structural plasticity2011
Author(s)
Lakhanpal, G., Kim, K., Kato-Hayashi, M., Hayashi, Y., Okamoto, K
Organizer
SfN 2011
Place of Presentation
Washington DC, USA
Year and Date
20111100
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[Presentation] CaMKII gates rapid structural plasticity in hippocampal dendritic spines2011
Author(s)
Kim, K., Hayashi, M., Narayanan, R., Suzuki, A., Matsuura, K., Okamoto, K., Hayashi, Y
Organizer
SfN 2011
Place of Presentation
Washington DC, USA
Year and Date
20111100
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[Presentation] In vivo two-photon imaging of neuronal circuit activity using transgenic mice that express fluorescent calcium sensor proteins in the brain2011
Author(s)
Sato, M., Kawano, M., Islam, T., Yamaguchi, Y., Ohkura, M., Nakai, J., Hayashi, Y
Organizer
第34回日本神経科学大会
Place of Presentation
横浜
Year and Date
20110900
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