2011 Fiscal Year Final Research Report
Elucidation of the genetic factors in rat epileptic seizures
| Project/Area Number |
20240042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURAMOTO Takashi 京都大学, 医学研究科, 准教授 (20311409)
MASHIMO Tomoji 京都大学, 医学研究科, 特定准教授 (80397554)
OHNO Yukihiro 大阪薬科大学, 薬学部, 教授 (00432534)
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| Project Period (FY) |
2008 – 2011
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| Keywords | てんかん / ラット / 疾患モデル / 原因遺伝子 / NER / コンジェニック系統 / 遺伝解析 / BACクローン |
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| Research Abstract |
Using an epilepsy rat model NER and a non-epileptic rat strain F344, we generated several congenic lines for two seizure-related QTLs. Comprehensive gene expression analyses in the brains of NER and a seizure-resistant NER. F344 double congenic strain revealed that one unknown gene and other six known genes were differentially expressed. Thus, we succeeded to disclose possible candidates for genetic factors contributing to seizure susceptibility.
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[Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel(Nav1. 1) confers susce ptibility to febrile seizures in rats2010
Author(s)
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T
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Journal Title
J Neurosci
Volume: 30(16)
Pages: 5744-5753
DOI
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