2010 Fiscal Year Final Research Report
Development of multifunctional polymeric micelles for systemic siRNA delivery
| Project/Area Number |
20240046
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATAOKA Kazunori The University of Tokyo, 大学院・工学系研究科, 教授 (00130245)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Nobuhiro 東京大学, 大学院・医学系研究科, 准教授 (10372385)
ITAKA Keiji 東京大学, 大学院・医学系研究科, 特任准教授 (60292926)
ISHII Takehiko 東京大学, 大学院・工学系研究科, 特任助教 (80415075)
MIYATA Kanjiro 東京大学, 大学院・医学系研究科, 助教 (50436523)
OSADA Kensuke 東京大学, 大学院・工学系研究科, 特任講師 (10396947)
YAMASAKI Yuichi 東京大学, 大学院・工学系研究科, 准教授 (00322678)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ドラッグデリバリー / 高分子ミセル / siRNA / がん治療 / 機能性ポリマー |
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| Research Abstract |
For successful systemic siRNA delivery towards cancer treatments, this study was aimed to develop the multifunctional polymeric micelles to safely and efficiently deliver siRNA into the cytoplasm of cancerous cells. Eventually, the micelle carrier, which was equipped with a targeting peptide ligand on the surface and stabilized core by 2-iminothiolane-modified polylysine, has achieved the significant growth inhibition of the subcutaneous tumor.
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