2010 Fiscal Year Final Research Report
Nucleic acid-based nanomachine systems for tumor treatment
| Project/Area Number |
20240049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu University |
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Principal Investigator |
MARUYAMA Atsushi Kyushu University, 先導物質化学研究所, 教授 (40190566)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 機能性核酸 / 核酸シャペロン / 医薬送達システム / 高分子電解質複合体 / グラフトコポリマー / 構造転移 / ナノマシン |
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| Research Abstract |
In this research project, we studied polymer materials to construct therapeutic nanomachine systems for tumor treatment. Polymer materials that accumulates in tumor tissues and exhibits nucleic acid chaperoning activity were designed and evaluated. Cationic comb-type copolymers having hydrophilic graft chains were found to accumulate effectively in tumor tissue subcutaneously implanted in mice. The copolymer was also found to facilitate structural transition between stem-loop structure and duplex and assembly of quadruplex DNA. These results suggested that activity of functional nucleic acids could be regulated with the cationic copolymers at tumor sites.
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