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2012 Fiscal Year Final Research Report

Research on rehabilitation for the osteochondral grafting surgeryand cartilage lesions

Research Project

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Project/Area Number 20240057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKyoto University

Principal Investigator

KUROKI Hiroshi  京都大学, 医学研究科, 教授 (20170110)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Yasuaki  京都医療センター臨床研究センター, 臨床研究企画運営部, 研究員 (90293860)
KOBAYASHI Masahiko  京都大学, 医学研究科, 講師 (20378623)
Project Period (FY) 2008 – 2012
Keywords骨軟骨移植 / 関節軟骨 / 軟骨損傷 / リハビリテーション / 超音波
Research Abstract

The major goal of the present study is to indicate evidences on intervention of rehabilitation for the osteochondral grafting surgery and cartilage lesions. We obtained the evidencethat normal knee function was recovered in human subjects at postoperative one year of the osteochondralgrafting surgery and thatnormal findings of cartilage were observed at postoperative oneyear ofthesurgery for rabbits.

  • Research Products

    (50 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Effects of Exercise Level on Biomarkers ina Rat Knee Model of Osteoarthritis.2013

    • Author(s)
      Yamaguchi S, Aoyama T, Ito A, Nagai M,Iijima H, Zhang X, Tajino J, Kuroki H
    • Journal Title

      JOrthop Res.

    • DOI

      doi:10.1002/jor.22332.

    • Peer Reviewed
  • [Journal Article] Low-intensity pulsedultrasound inhibits messenger RNAexpression of matrix metalloproteinase-13induced by interleukin-1 β inchondrocytes in an intensity-dependentmanner.2012

    • Author(s)
      Ito A, Aoyama T, Yamaguchi S, Zhang X,Akiyama H, Kuroki H.
    • Journal Title

      Ultrasound Med Biol.

      Volume: 38(10) Pages: 1726-33

    • DOI

      doi:10.1016/j.ultrasmedbio.2012.06.005

    • Peer Reviewed
  • [Journal Article] 低出力超音波パルス療法が関節軟骨代謝に与える即時的影響 異なる刺激強度を用いた研究2012

    • Author(s)
      伊藤明良, 青山朋樹, 山口将希, 秋山治彦, 黒木裕士.
    • Journal Title

      理学療法学

      Volume: 39(5) Pages: 307-313

    • Peer Reviewed
  • [Journal Article] Fiber components ofthe shoulder superior labrum.2012

    • Author(s)
      Arai R, Kobayashi M, Toda Y, Nakamura S,Miura T, Nakamura T.
    • Journal Title

      Surg RadiolAnat.

      Volume: 34(1) Pages: 49-56

    • DOI

      doi:10.1007/s00276-011-0840-8

    • Peer Reviewed
  • [Journal Article] 解剖学的二重束ACL再建術の短期成績とイメージマッチング法による術前回旋不安定性評価2012

    • Author(s)
      小林雅彦、中村伸一郎、新井隆三、浅野太洋、中川泰彰、中村孝志
    • Journal Title

      整スポ会誌

      Volume: 32巻2号 Pages: 119-123

    • Peer Reviewed
  • [Journal Article] Longitudinal evaluation ofcartilage after osteochondral autogenoustransfer with delayed gadolinium-enhancedMRI of the cartilage (dGEMRIC).2012

    • Author(s)
      Shirai T, Kobayashi M, Nakamura S, AraiR, Nishitani K, Satake T, Dahlberg LE,Kuroki H, Nakagawa Y, Okada T, Togashi K,Nakamura T.
    • Journal Title

      J OrthopRes.

      Volume: 30(2) Pages: 221-5

    • DOI

      doi:10.1002/jor.21514.

    • Peer Reviewed
  • [Journal Article] Image-matchingtechnique can detect rotational and APinstabilities in chronic ACL-deficientknees.2011

    • Author(s)
      Nakamura S, Kobayashi M, Asano T, AraiR, Nakagawa Y, Nakamura T.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 19 Suppl 1 Pages: 69-76

    • Peer Reviewed
  • [Journal Article] Chondroprotective effect ofalendronate in a rabbit model ofosteoarthritis.2011

    • Author(s)
      Shirai T, Kobayashi M, Nishitani K,Satake T, Kuroki H, Nakagawa Y, NakamuraT.
    • Journal Title

      J Orthop Res.

      Volume: 29(10) Pages: 1572-7

    • DOI

      doi:10.1002/jor.21394.Epub2011Apr1.

    • Peer Reviewed
  • [Journal Article] Care should especially be taken concerningknee joint angle and the contact area inrehabilitation planned followingautologous osteochondral grafting forknee cartilage lesions: A report of twocases.2011

    • Author(s)
      Hiroshi Kuroki, Toru Oka, Taizo Furukawa,Masahiko Kobayashi, Yasuaki Nakagawa.
    • Journal Title

      ICRS Newsletter

      Volume: Winter Issue 14 Pages: 41-42

    • Peer Reviewed
  • [Journal Article] Fluoroscopic and computed tomographicanalysis of knee kinematics during verydeep flexion after total knee arthroplasty2010

    • Author(s)
      Nakamura S, Takagi H, Asano T, NakagawaY, Kobayashi M, and Nakamura T.
    • Journal Title

      J Arthroplasty

      Volume: 25:3 Pages: 486-491

    • Peer Reviewed
  • [Journal Article] The Bi-Surface totalknee arthroplasty: minimum 10-yearfollow-up study.2010

    • Author(s)
      Nakamura S, Kobayashi M, Ito H, NakamuraK, Ueo T, Nakamura T.
    • Journal Title

      Knee.

      Volume: 17(4) Pages: 274-8

    • Peer Reviewed
  • [Journal Article] Structural damageand chemical contaminants on reprocessedarthroscopic shaver blades2009

    • Author(s)
      Kobayashi M, Nakagawa Y, Okamoto Y,Nakamura S, Nakamura T.
    • Journal Title

      Am J SportsMed

      Volume: 37(2) Pages: 266-73

    • Peer Reviewed
  • [Journal Article] Ultrasound has thepotential to detect degeneration ofarticular cartilage clinically, even ifthe information is obtained from anindirect measurement of intrinsicphysical characteristics.2009

    • Author(s)
      Kuroki H, Nakagawa Y, Mori K, KobayashiM, Yasura K, Okamoto Y, Suzuki T, NishitaniK, Nakamura T.
    • Journal Title

      Arthritis ResTher

      Volume: 11(3) Pages: 408

    • Peer Reviewed
  • [Journal Article] Ultrasound properties ofarticular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis.2009

    • Author(s)
      Kuroki H, Nakagawa Y, Mori K, KobayashiM, Nakamura S, Nishitani K, Shirai T,Nakamura T.
    • Journal Title

      Knee Surg Sports TraumatolArthrosc

      Volume: 17(1) Pages: 11-8

    • Peer Reviewed
  • [Journal Article] Positive effect of Alendronate onsubchondral bone healing and subsequentcartilage repair in a rabbit osteochondraldefect model.2009

    • Author(s)
      Nishitani K, Shirai T, Kobayashi M,Kuroki H, Azuma Y, Nakagawa Y, Nakamura T.
    • Journal Title

      Am J Sports Med

      Volume: 37(Suppl 1) Pages: 139S-47S

    • Peer Reviewed
  • [Journal Article] 距骨骨軟骨障害(OLT)に対する骨軟骨移植術(OAT)2009

    • Author(s)
      小林与人、小林雅彦、中村伸一郎、中川泰彰、中村孝志
    • Journal Title

      中部整災誌

      Volume: 52 Pages: 1019-1020

    • Peer Reviewed
  • [Journal Article] Ultrasound properties ofarticular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis.2009

    • Author(s)
      Kuroki H, Nakagawa Y, Mori K, KobayashiM, Nakamura S, Nishitani K, Shirai T,Nakamura T.
    • Journal Title

      Knee Surg Sports TraumatolArthrosc.

      Volume: 17(1) Pages: 11-8

    • Peer Reviewed
  • [Journal Article] Ultrasound propertiesof articular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis.2009

    • Author(s)
      Hiroshi Kuroki, Yasuaki Nakagawa, KojiMori, Masahiko Kobayashi, ShinichiroNakamura, Kohei Nishitani, Takaaki Shirai,Takashi Nakamura
    • Journal Title

      Knee Surgery, SportsTraumatology, Arthroscopy

      Volume: 17(1) Pages: 11-18

    • Peer Reviewed
  • [Journal Article] Positive effect of alendronate onsubchondral bone healing and subsequentcartilage repair in a rabbit osteochondraldefect model.2009

    • Author(s)
      Nishitani K, Shirai T, Kobayashi M,Kuroki H, Azuma Y, Nakagawa Y, Nakamura T
    • Journal Title

      American Journal of SportsMedicine

      Volume: 37(Suppl.1) Pages: 139S-147S

    • Peer Reviewed
  • [Journal Article] 反復性膝蓋骨脱臼に対する内側膝蓋大腿靱帯再建術後の理学療法の経験 筋力強化運動とROM運動についての検討2009

    • Author(s)
      岡 徹, 黒木裕士, 水野泰行, 古川泰三
    • Journal Title

      理学療法ジャーナル

      Volume: 43(12) Pages: 1067-1071

    • Peer Reviewed
  • [Journal Article] 少年野球選手に対するメディカルチェックを実施して2009

    • Author(s)
      岡 徹,黒木裕士, 秋山奈菜子, 長谷川聡, 古川泰三, 水野泰行
    • Journal Title

      スポーツ障害の予防と啓蒙活動.理学療法京都

      Volume: 38 Pages: 66-67

    • Peer Reviewed
  • [Journal Article] 膝離断性骨軟骨炎に対する骨軟骨移植術後の膝機能とリハビリテーション4症例の短期経過.2009

    • Author(s)
      岡 徹, 黒木裕士, 水野泰行, 古川泰三, 中川泰彰
    • Journal Title

      膝

      Volume: 33(1) Pages: 74-78

    • Peer Reviewed
  • [Journal Article] Ultrasound properties ofarticular cartilage in the tibio-femoral joint in knee osteoarthritis: relation toclinical assessment (InternationalCartilage Repair Society grade)2008

    • Author(s)
      Kuroki H, Nakagawa Y, Mori K, KobayashiM, Yasura K, Okamoto Y, Suzuki T, NishitaniK, Nakamura T
    • Journal Title

      Arthritis Res Ther.

      Volume: 10(4) Pages: R78

    • Peer Reviewed
  • [Journal Article] 下肢の日帰り手術2008

    • Author(s)
      中川泰彰、小林雅彦、中村伸一郎、中村孝志
    • Journal Title

      整形外科最小侵襲手術ジャーナル

      Volume: 47 Pages: 49-54

    • Peer Reviewed
  • [Journal Article] Ultrasound properties of articularcartilage in knee osteoarthritis:relation to clinical assessment (International Cartilage Repair Societygrade).2008

    • Author(s)
      Hiroshi Kuroki, Yasuaki Nakagawa, KojiMori, Masahiko Kobayashi, Ko Yasura,Yukihiro Okamoto, Takashi Suzuki, KoheiNishitani and Takashi Nakamura.
    • Journal Title

      Arthritis Research & Therapy

      Volume: 10 Pages: R78

    • Peer Reviewed
  • [Journal Article] 遠位上腕二頭筋腱断裂術後の早期理学療法の経験.2008

    • Author(s)
      岡 徹,黒木裕士,古川泰三,水野泰行
    • Journal Title

      理学療法ジャーナル

      Volume: 42(10) Pages: 895-898

    • Peer Reviewed
  • [Journal Article] 膝関節骨・軟骨疾患に対する骨軟骨移植術(モザイクプラスティ)後の機能回復経過 ~40歳未満群と40歳以上群の比較~2008

    • Author(s)
      岡 徹,黒木裕士,水野泰行,古川泰三,中川泰彰
    • Journal Title

      運動療法と物理療法

      Volume: 19(1) Pages: 50-5

    • Peer Reviewed
  • [Journal Article] 膝離断性骨軟骨炎に対する骨軟骨移植術後の膝機能とリハビリテーション~4 症例の短期経過~2008

    • Author(s)
      岡 徹,黒木裕士,水野泰行,古川泰三,中川泰彰
    • Journal Title

      膝

      Volume: 33(1) Pages: 74-78

    • Peer Reviewed
  • [Journal Article] Intraoperativeacoustic evaluation of living humancartilage of the elbow and knee duringmosaicplasty for osteochondritisdissecans of the elbow.

    • Author(s)
      Nishitani K, Nakagawa Y, Mori K,Kobayashi M, Nakamura T.
    • Journal Title

      Am J Sports Med

      Volume: 36(12) Pages: 2345-53

    • Peer Reviewed
  • [Presentation] Culturing temperature affectschondrocyte differentiation andextracellular matrix formation.2013

    • Author(s)
      Ito A, Aoyama T, Tajino J, Nagai M,Yamaguchi S, Iijima H, Zhang X, Akiyama H,Kuroki H.
    • Organizer
      OARSI 2013
    • Place of Presentation
      MarriottPhiladelphia Downtown, Philadelphia, USA
    • Year and Date
      20130418-23
  • [Presentation] Is cartilage andsubchondral bone covered by menisci weak2013

    • Author(s)
      Iijima H, Aoyama T, Ito A, Tajino J,Nagai M, Ito A, Zhang X, Yamaguchi S,Akiyama H, Kuroki H.
    • Organizer
      OARSI 2013
    • Place of Presentation
      MarriottPhiladelphia Downtown, Philadelphia, USA
    • Year and Date
      20130418-23
  • [Presentation] Changes on the expression of CD44 inimmobilized knee in rats2013

    • Author(s)
      Nagai M, Ito A, Zhang X, Yamaguchi S,Iijima H, Tajino J, Aoyama T, Kuroki H.
    • Organizer
      OARSI 2013
    • Place of Presentation
      MarriottPhiladelphia Downtown, Philadelphia, USA
    • Year and Date
      20130418-23
  • [Presentation] 半月板被覆部軟骨は脆弱であるのか2013

    • Author(s)
      飯島弘貴,青山朋樹,伊藤明良,太治野純一,長井桃子,張 項凱,山口将希,秋山治彦,黒木裕士
    • Organizer
      第26回日本軟骨代謝学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      20130301-02
  • [Presentation] 温度環境が軟骨細胞外基質形成に与える影響2013

    • Author(s)
      伊藤明良,青山朋樹,長井桃子,山口将希,飯島弘貴,張 項凱,太治野純一,秋山治彦,黒木裕士
    • Organizer
      第26回日本軟骨代謝学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      20130301-02
  • [Presentation] 初期変形性膝関節症に対する骨軟骨移植術後の再鏡視像2012

    • Author(s)
      小林雅彦、新井隆三、原田豪人、築山浩之、中川泰彰
    • Organizer
      第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      20120719-21
  • [Presentation] ステロイド性骨壊死に対する自家骨軟骨移植術後の再鏡視所見. 第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)2012

    • Author(s)
      築山浩之、小林雅彦、新井隆三、原田豪人
    • Organizer
      第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      20120719-21
  • [Presentation] Functionalrecovery after autologous osteochondraltransplantation (mosaicplasty).2012

    • Author(s)
      H. Kuroki, T. Oka, T. Furukawa, M.Kobayashi, Y. Nakagawa.
    • Organizer
      The 18thEuropean Congress of Physical &Rehabilitation Medicine
    • Place of Presentation
      Thessaloniki, Greece.
    • Year and Date
      20120528-0601
  • [Presentation] 低出力超音波パルスは強度依存性に軟骨破壊因子を抑制する2012

    • Author(s)
      伊藤明良,山口将希,張項凱,黒木裕士
    • Organizer
      第47回日本理学療法学術大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      20120525-27
  • [Presentation] ACLT モデルラットに対する運動負荷が関節軟骨に及ぼす影響2012

    • Author(s)
      山口将希,黒木裕士,伊藤明良,張項凱
    • Organizer
      第47回日本理学療法学術大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      20120525-27
  • [Presentation] LOW-INTENSITY PULSEDULTRASOUND INHIBITS MESSENGER RNAEXPRESSION OF MATRIX METALLOPROTEINASE-13IN RAT CHONDROCYTES.2012

    • Author(s)
      Kuroki H, Ito A, Zhang X, Yamaguchi S,Aoyama T, Akiyama H
    • Organizer
      EUROSON 2012
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      20120422-24
  • [Presentation] Low-intensity pulsed ultrasoundinhibits messenger RNA expression of MMP13induced by interleukin-1β inintensity-dependent manner onchondrocytes.2012

    • Author(s)
      Akira Ito, Xiang Kai Zhang, SyokiYamaguchi, Haruhiko Akiyama, Hiroshi Kuroki
    • Organizer
      EUROSON 2012
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      20120422-24
  • [Presentation] Chondroprotectiveeffect of Alendronate in a rabbit model ofosteoarthritis.2012

    • Author(s)
      T. Shirai, M. Kobayashi, K. Nishitani,T. Satake, H. Kuroki, Y. Nakagawa, C.Tanaka, T. Nakamura.
    • Organizer
      EUROSON 2012
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      20120422-24
  • [Presentation] 初期変形性膝関節症に対する骨軟骨移植術2012

    • Author(s)
      小林雅彦、原田豪人、築山浩之、中川泰彰
    • Organizer
      第118回中部日本整形外科災害外科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20120406-07
  • [Presentation] 初期変形性膝関節症患者に対する機能的電気刺激トレーニングの効果2012

    • Author(s)
      小林 雅彦、長谷川 聡、原田豪人、築山浩之
    • Organizer
      第118回中部日本整形外科災害外科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20120406-07
  • [Presentation] 膝前十字靭帯再再建術症例の検討2012

    • Author(s)
      築山浩之, 小林雅彦, 原田豪人 水野泰行 岩城公一
    • Organizer
      第118回中部日本整形外科災害外科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20120406-07
  • [Presentation] IL-1βにより惹起されたMMP13mRNA発現亢進に対する低出力超音波パルスの即時的効果.2012

    • Author(s)
      伊藤明良,山口将希,張 項凱,青山朋樹,秋山治彦,黒木裕士
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      ウィルあいち
    • Year and Date
      20120309-10
  • [Presentation] Optical coherence tomographyによる家兎自家骨軟骨柱移植術モデルの評価2012

    • Author(s)
      佐竹剛,小林雅彦,原田豪人,新井隆三,黒木裕士
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      ウィルあいち
    • Year and Date
      20120309-10
  • [Presentation] Low-intensitypulsed ultrasound downregulates themessenger RNA expression of the matrixmetalloproteinases on an articularcartilage explants model.2011

    • Author(s)
      Akira Ito, Tomoki Aoyama, Hiroto Mitsui,Makoto Ishibashi, Shoki Yamaguchi, XiangKai Zhang, Hiroshi Kuroki.
    • Organizer
      The 2011 WorldCongress on Osteoarthritis
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-09-16
  • [Presentation] ANALYSIS OFMENISCUS USING FOURIER TRANSFORM INFRAREDIMAGING SPECTROSCOPY.2011

    • Author(s)
      Hiroshi Kuroki, Koji Tsuchimoto, MikikoKobayashi-Miura, Tomoki Aoyama, Akira Ito,Kojiro Hashimoto, Makoto Ishibashi, ShokiYamaguchi, Xiang Kai Zhang.
    • Organizer
      The 2011 WorldCongress on Osteoarthritis
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-09-16
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/pt0102/

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Published: 2014-08-29  

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