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2011 Fiscal Year Final Research Report

Investigation of Rapid and Continuous Separation Principle for Micro/Nano Structures Using Hydrodynamic Methods

Research Project

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Project/Area Number 20241031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionChiba University

Principal Investigator

SEKI Minoru  千葉大学, 大学院・工学研究科, 教授 (80206622)

Co-Investigator(Renkei-kenkyūsha) KUSHIDA Masato  千葉大学, 大学院・工学研究科, 准教授 (70177989)
YAMADA Masumi  千葉大学, 大学院・工学研究科, 特任准教授 (30546784)
Project Period (FY) 2008 – 2011
Keywords分離工学 / 微粒子分級 / 流体素子 / セルソーター / マイクロ流体工学 / 血液分析
Research Abstract

Novel hydrodynamic separation/classification principles using micro/nano-fluidic devices (PFF and HDF) were proposed for collecting uniform micro/nano structures such as particles, biological cells, droplets, bubbles, or supra-molecules with the diameter from sub-micron to several tens of microns. In this study, the mechanisms of the proposed separation schemes and the limit of application were investigated and clarified. And also, various separation systems using PFF or HDF methods were examined. Future applications in various basic studies and industrial fields are expected.

  • Research Products

    (26 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Isolation of Cell Nuclei in Microchannels by Short-term Chemical Treatment via Two-Step Carrier Medium Exchange2012

    • Author(s)
      K. Toyama, M. Yamada, M. Seki
    • Journal Title

      Biomedical Microdevices

      Volume: 14

    • DOI

      DOI:10.1007/s10544-012-9653-8

    • Peer Reviewed
  • [Journal Article] Generation of Uniform-Size Droplets by Multistep Hydrodynamic Droplet Division in Microfluidic Circuits2012

    • Author(s)
      T. Moritani, M. Yamada, M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 11 Pages: 601-610

    • DOI

      DOI:10.1007/s10404-011-0826-1

    • Peer Reviewed
  • [Journal Article] Fluidic Shear-Assisted Formation of Actuating Multilamellar Lipid Tubes Using Microfabricated Nozzle Array Device2012

    • Author(s)
      M. Masubuchi, T. Toyota, M. Yamada, M. Seki
    • Journal Title

      Chemical Communications

      Volume: 47 Pages: 8433-8455

    • DOI

      DOI:10.1039/c1cc11510c

    • Peer Reviewed
  • [Journal Article] Blood Cell Classification Utilizing Hydrodynamic Filtration2011

    • Author(s)
      M. Matsuda, M. Yamada, M. Seki
    • Journal Title

      Electronics and Communications in Japan

      Volume: 94 Pages: 1-6

    • DOI

      DOI:10.1002/ecj.10281

    • Peer Reviewed
  • [Journal Article] Sedimentation Pinchedflow Fractionation for Size and Densitybased Particle Sorting in Microchannels2011

    • Author(s)
      T. Morijiri, S. Sunahiro, M. Senaha, M. Yamada, M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 11 Pages: 105-110

    • DOI

      DOI:10.1007/s10404-011-0785-6

    • Peer Reviewed
  • [Journal Article] Observation of Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2011

    • Author(s)
      S. Sugaya, M. Yamada M. Seki
    • Journal Title

      Biomicrofluidics

      Volume: 5 Pages: 024103 (13)

    • DOI

      DOI:10.1063/1.3580757

    • Peer Reviewed
  • [Journal Article] In-channel Focusing of Flowing Microparticles Utilizing Hydrodynamic Filtration2009

    • Author(s)
      R. Aoki, M. Yamada, M. Yasuda M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 6 Pages: 571-576

    • DOI

      DOI:10.1007/s10404-008-0334-0

    • Peer Reviewed
  • [Journal Article] Continuous and Size-Dependent Sorting of Emulsion Droplets Using Hydrodynamics in Pinched Microchannel2008

    • Author(s)
      H. Maenaka, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Langmuir

      Volume: 24 Pages: 4405-4410

    • DOI

      DOI:10.1021/la703581j

    • Peer Reviewed
  • [Journal Article] Millisecond Treatment of Cells Using Microfluidic Devices via Two-Step Carrier-Medium Exchange2008

    • Author(s)
      M. Yamada, J. Kobayashi, M. Yamato, M. Seki, T. Okano
    • Journal Title

      Lab Chip

      Volume: 8 Pages: 772-778

    • DOI

      DOI:10.1039/b718281c

    • Peer Reviewed
  • [Journal Article] Continuous and Precise Particle Separation by Electroosmotic Flow Control in Microfluidic Devices2008

    • Author(s)
      T. Kawamata, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Electrophoresis

      Volume: 29 Pages: 1423-1430

    • DOI

      DOI:10.1002/elps.200700658

    • Peer Reviewed
  • [Presentation] マイクロ流体システムにおける微量操作と分離法に関する研究2012

    • Author(s)
      関実
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      東京
    • Year and Date
      20120314-17
  • [Presentation] Microfluidics and Microfabrication Technology for Highly Precise Cell Manipulation and Cultivation,2011

    • Author(s)
      M. Yamada, M. Seki
    • Organizer
      2011 Intl Symp. on Micro-Nano Mechatronics and Human Science (IEEE-MHS2011)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20111106-09
  • [Presentation] Tilted-Branch Hydrodynamic Filtration for Length-dependent Sorting of Rod-like Particles2011

    • Author(s)
      A. Tamura, S. Sugaya, M. Yamada, M. Seki
    • Organizer
      15th Intl Conf. on Miniaturized Systems for Chem. and Life Sci. (MicroTAS2011)
    • Place of Presentation
      Seattle, USA
    • Year and Date
      20111002-06
  • [Presentation] Continuous Microfluidic Processes for Cell Manipulation, Separation, and Cultivation Systems2011

    • Author(s)
      M. Yamada, M. Seki
    • Organizer
      The 11th Intl Symp. on Microchem. and Microsys. (ISMM2011)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20110602-04
  • [Presentation] Continuous and Rapid Separation of Soft Matters Using Microfluidic Systems2010

    • Author(s)
      M. Seki, M. Yamada
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20101215-20
  • [Presentation] Bubble-based Continuous Separation System in Microfluidic Device2010

    • Author(s)
      A. Kobayashi, M. Yamada, M. Seki
    • Organizer
      MicroTAS2010
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      20101003-07
  • [Presentation] Two-dimensional Cell Sorting Device Employing Pinched-flow Fractionation and Magnetophoresis2010

    • Author(s)
      M. Senaha, R. Mitamura, M. Yamada, M. Seki
    • Organizer
      MicroTAS2010
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      20101003-07
  • [Presentation] Continuous and Rapid Separation of Micro/Nano-Structures Using Microfluidic Systems2009

    • Author(s)
      M. Seki
    • Organizer
      13th Annual European Conf. on Micro & Nanoscale Technol. for the Biosci. (NanoBioTech-Montreux 2009)
    • Place of Presentation
      Montreux, Switzerland
    • Year and Date
      20091116-18
  • [Presentation] Visualizing Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2009

    • Author(s)
      S. Sugaya, M. Yamada, M. Seki
    • Organizer
      MicroTAS2009
    • Place of Presentation
      Jeju Island, Korea
    • Year and Date
      20091101-05
  • [Presentation] Pinched Flow Fractionation Device for Size and Density-Dependent Separation of Particles Utilizing Centrifugal Pumping2008

    • Author(s)
      S. Sunahiro, M. Senaha, M. Yamada, M. Seki
    • Organizer
      MicroTAS2008
    • Place of Presentation
      Diego, USA
    • Year and Date
      20081012-16
  • [Book] 「イムノアッセイチップ」,in「バイオチップ実用化ハンドブック」2010

    • Author(s)
      関実
    • Total Pages
      610
    • Publisher
      NTS
  • [Book] 「粒子ハンドリング」,in「マイクロ・ナノ化学チップと医療・環境・バイオ分析」2009

    • Author(s)
      関実
    • Total Pages
      459
    • Publisher
      技術教育出版(NTS)
  • [Book] 「マイクロ・ナノ流体デバイスを用いた細胞,分離」,in「細胞分離・操作技術の最前線」2008

    • Author(s)
      関実
    • Total Pages
      387
    • Publisher
      シーエムシー
  • [Remarks]

    • URL

      http://chem.tf.chiba-u.jp/gacb01/Research/content-separation.html

  • [Patent(Industrial Property Rights)] エルトリエータ用マイクロ流路システムおよび粒子分離方法2010

    • Inventor(s)
      関実, 山田真澄, 森尻智樹, 疋田敏勝
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      特許、特願2010-223564
    • Filing Date
      2010-10-01
  • [Patent(Industrial Property Rights)] 連続的2次元粒子分離装置および粒子分離方法2010

    • Inventor(s)
      関実, 山田真澄, 瀬名波匡, 三田村龍典
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      特許、特願2010-223550
    • Filing Date
      2010-10-01

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Published: 2013-07-31  

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