2010 Fiscal Year Final Research Report
ChIP-chip analysis of diversity of binding sites of transcriptional factors in thres E.coli strains
| Project/Area Number |
20241045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
OGASAWARA Naotake Nara Institute of Science and Technology, 情報科学研究科, 教授 (10110553)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Taku 奈良先端科学技術大学院大学, 情報科学究科, 助教 (50346318)
KUROKAWA Ken 東京工業大学, 生命理工学研究科, 教授 (20343246)
TOBE Toru 大阪大学, 大学院・医学研究科, 准教授 (70207596)
SUZUKI Yutaka 東京大学, 大学院・新領域創成科学研究科, 准教授 (40323646)
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| Co-Investigator(Renkei-kenkyūsha) |
AIBA Hirofumi 名古屋大学, 生命農学研究科, 准教授 (60211687)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ゲノム進化・再編 / ChIP-chip / 転写制御ネットワーク |
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| Research Abstract |
We performed ChIP-chip and ChAP-seq analysis to determine the diversity of binding profiles of transcriptional regulators and transcriptional networks among different E.coli strains. Our analysis revealed that the binding profiles are highly conserved in different E.coli strains, suggesting strongly that the binding profile of atranscriptional regulator is kept even in different E.coli strains which have highly diverse genome structures.
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[Journal Article] J Bacteriol2009
Author(s)
Uyar E, Kurokawa K, Yoshimura M, Ishikawa S, Ogasawara N, Oshima T.
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Journal Title
Differential binding profiles of StpA in wild-type and h-ns mutant cells : a comparative analysis of cooperative partners by chromatin immunoprecipitation-microarray analysis. 191
Pages: 2388-2391
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