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2010 Fiscal Year Self-evaluation Report

Modular strategy to construct functional ribonucleopeptides

Research Project

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Project/Area Number 20241051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionKyoto University

Principal Investigator

MORII Takashi  Kyoto University, エネルギー理工学研究所, 教授 (90222348)

Project Period (FY) 2008 – 2011
Keywords生体高分子 / 核酸・タンパク質 / 生体認識・機能化学 / モジュール / センサー / 分子認識 / ケミカルバイオロジー / RNA
Research Abstract

(1)RNAモジュール構造をもとにしたセンシングRNPの構築
(1)申請者らが開発したATP結合性RNPセンサーのRNA二次構造を系統的に解析し、特定の蛍光分子の蛍光強度の変化に特異的に寄与する二次構造モジュール(蛍光モジュール)を同定する。
(2)同定された蛍光モジュールを既知のRNAアプタマーに導入してセンサー化し、蛍光モジュールの汎用性を検証する。

  • Research Products

    (5 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Structural Aspectsfor the Recognition of ATP byRibonucleopeptide Receptors.2011

    • Author(s)
      Nakano, S., Mashima, T., Matsugami, A., Inoue,M., Katahira, M., Morii, T.
    • Journal Title

      J.Am.Chem.Soc. 133

      Pages: 4567-79

    • Peer Reviewed
  • [Journal Article] Context-dependent fluorescence detection of aphosphorylated tyrosine residue by aribonucleopeptide.2008

    • Author(s)
      Hasegawa, T., Hagiwara, M., Fukuda, M.,Nakano, S., Fujieda, N., Morii, T.
    • Journal Title

      J.Am.Chem.Soc. 130

      Pages: 8804-8812

    • Peer Reviewed
  • [Presentation] Molecular Recognitiom byRibonucleopeptides.2010

    • Author(s)
      Takashi Morii
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-12-19
  • [Presentation] A modular strategy for tailoringfunctional ribonucleopeptide complexes.2009

    • Author(s)
      Takashi Morii
    • Organizer
      2ndSwitzerland-Japan Biomolecular ChemistrySymposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-09-11
  • [Book] Biosensors for Health,Environment and Biosecurity(Recent progress in the construction methodologyof fluorescent biosensors based onbiomolecules.)2011

    • Author(s)
      Nakata, E., Liew, F.-F., Nakano, S., Morii, T.
    • Publisher
      InTech

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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