2010 Fiscal Year Final Research Report
Chemical synthesis of glycans and glycoconjugates for elucidation of their functions in immune and nerve system
Project/Area Number |
20241053
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Osaka University |
Principal Investigator |
FUKASE Koichi Osaka University, 大学院・理学研究科, 教授 (80192722)
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Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Yukari 大阪大学, 大学院・理学研究科, 准教授 (00362616)
TANAKA Katsunori 大阪大学, 大学院・理学研究科, 助教 (00403098)
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Project Period (FY) |
2008 – 2010
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Keywords | 糖鎖 / 自然免疫 / PETイメージング / グリコシル化 / 固相合成 / 免疫増強 / 複合糖質 / 糖タンパク質 |
Research Abstract |
New synthetic methods have been developed for glycans and glycoconjugates and applied them to the synthesis of complex bioactive molecules for the elucidation of action mechanisms. In particular, immunostimulating or immunomodulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthetic ligands for the innate immune receptors were used for the immune regulation. Bio-imaging studies of glycans and glycoproteins were also studied for the dynamic and kinetic analysis of glycans to unveil the unknown function of glycans.
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[Journal Article] Non-invasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure.2010
Author(s)
Tanaka, K., Siwu, R.O.E., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K., Chen, C.W., Paulson, C.J., Watanabe, Y., Fukase, K.
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Journal Title
Angew.Chem.Int.Ed. 49
Pages: 8195-8200
Peer Reviewed
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[Journal Article] A combined 6p-azaelectrocyclization/ staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes.2010
Author(s)
Tanaka, K., Minami, K., Tahara, T., Siwu, E.R.O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., Fukase, K.
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Journal Title
J.Carbohydr.Chem. 29
Pages: 118-132
Peer Reviewed
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[Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking.2010
Author(s)
Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R.O., Nozaki, S.; Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K.
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Journal Title
Chem Med Chem (5)
Pages: 841-845
Peer Reviewed
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[Journal Article] Lipopeptides from Staphylococcus aureus as Tlr2 Ligands : Prediction with mRNA Expression.2009
Author(s)
Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., Fukase, K.
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Journal Title
ChemBioChem. 10(14)
Pages: 2311-2315
Peer Reviewed
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[Journal Article] Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions.2009
Author(s)
Fujimoto, Y., Konishi, Y., Kubo, O., Hasegawa, M., Inohara, N., Fukase, K.
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Journal Title
Tetrahedron Lett. 50
Pages: 3631-3634
Peer Reviewed
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[Journal Article] Synthesis of a sialic acid containing complex-type N-glycan on a solid support.2009
Author(s)
Tanaka, K., Fujii, Y., Tokimoto, H., Mori, Y. Tanaka, S. Bao, G., Siwu, E.R.O., Nakayabu, A., Fukase, K.
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Journal Title
Chem.Asian J. 4
Pages: 574-580
Peer Reviewed
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[Journal Article] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions.2008
Author(s)
Kawasaki, A., Karasudani, Y., Otsuka, Y., Hasegawa, M., Inohara, N., Fujimoto, Y., Fukase, K.
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Journal Title
Chem., Eur., J. 14
Pages: 10318-10330
Peer Reviewed
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[Journal Article] Synthesis of Rubrivivax gelatinosus lipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities.2008
Author(s)
Fukase, Y., Fujimoto, Y., Adachi, Y., Suda, Y., Kusumoto, S., Fukase, K.
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Journal Title
Bull.Chem.Soc.Jpn. BCSJ Award article 81
Pages: 796-819
Peer Reviewed
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[Journal Article] A submicrogram scale protocol for biomolecule-based PET imaging by rapid 6π-azaelectrocyclization : visualization of sialic acid dependent circulatory3 residence of glycoproteins.2008
Author(s)
Tanaka, K., Masuyama, T., Hasegawa, K., Tahara, T., Mizuma, H., Wada, Y., Watanabe, Y., Fukase, K.
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Journal Title
Angew.Chem.Int.Ed. 47
Pages: 102-105
Peer Reviewed
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[Presentation] Synthesisof new probes for chemical glycobiology : application to PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells2009
Author(s)
Koichi Fukase, Katsunori Tanaka, TatsuroMasuyama, Kaori Minami, Eric R.O. Siwu, KokiHasegawa, Tsuyoshi Tahara, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe
Organizer
The Second International Symposium on Combinatorial Sciences in Chemistry, Biology,Catalysts and Materials (SCS09)
Place of Presentation
Beijin, China, Invited
Year and Date
20090919-20090923
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