2010 Fiscal Year Final Research Report
Construction of Drug-Discovering System by using Multiple Fluorescent Labels on Peptide Library
| Project/Area Number |
20241054
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Okayama University |
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Principal Investigator |
SISIDO Masahiko Okayama University, 大学院・自然科学研究科, 特命教授(研究) (60026268)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMATSU Mizuki 岡山大学, 大学院・自然科学研究科, 助教 (60379716)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蛍光性アミノ酸 / ペプチドライブラリー / がん細胞 / インビトロスクリーニング / ステルス標識 / 2次元蛍光スペクトル |
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| Research Abstract |
A lot of researchers have been trying to discover peptides that bind onto specific cancer cells, however, without success. A major reason for the unsucceesful attempts may be that the discovery processes have been done under conditions far from the conditions inside the living body. The purpose of this project is to establish a novel screening process by using multiple fluorescent labels on peptide library. Putting a solution of the peptide library onto cancer cells and identifying those bound onto the cells with fluorescence spectroscopy, we found several cancer cell specific octapeptides.
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