2011 Fiscal Year Final Research Report
Functional Funnel of Molecular Motors
| Project/Area Number |
20244068
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Nagoya University |
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Principal Investigator |
SASAI Masaki 名古屋大学, 工学研究科, 教授 (30178628)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 分子モーター / 粗視化モデル / アロステリック変形 |
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| Research Abstract |
Protein motors show the superior abilities in working efficiently at the mild temperature by responding flexibly to the applied load. In this research project, protein machines were studied theoretically to reveal their physical principles :(1) Coarse-grained models were constructed to analyze the large structural fluctuation of myosins and other proteins, and the theoretical framework to understand allosteric transitions is developed,(2) the millisecond time-scale trajectories of moving proteins were simulated, and(3) the functional funnel hypothesis of molecular motors was proposed and critically examined.
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